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Melissa P Lokugamage
Melissa P Lokugamage
82VS, Alloy Therapeutics
Verified email at alloytx.com - Homepage
Title
Cited by
Cited by
Year
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
CD Sago, MP Lokugamage, K Paunovska, DA Vanover, CM Monaco, ...
Proceedings of the National Academy of Sciences 115 (42), E9944-E9952, 2018
2392018
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs
MP Lokugamage, D Vanover, J Beyersdorf, MZC Hatit, L Rotolo, ...
Nature biomedical engineering 5 (9), 1059-1068, 2021
1992021
Nanoparticles containing oxidized cholesterol deliver mRNA to the liver microenvironment at clinically relevant doses
K Paunovska, AJ Da Silva Sanchez, CD Sago, Z Gan, MP Lokugamage, ...
Advanced materials 31 (14), 1807748, 2019
1422019
Constrained nanoparticles deliver siRNA and sgRNA to T cells in vivo without targeting ligands
MP Lokugamage, CD Sago, Z Gan, BR Krupczak, JE Dahlman
Advanced Materials 31 (41), 1902251, 2019
1112019
Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery
K Paunovska, CJ Gil, MP Lokugamage, CD Sago, M Sato, GN Lando, ...
ACS nano 12 (8), 8341-8349, 2018
1092018
Nanoparticles that deliver RNA to bone marrow identified by in vivo directed evolution
CD Sago, MP Lokugamage, FZ Islam, BR Krupczak, M Sato, JE Dahlman
Journal of the American Chemical Society 140 (49), 17095-17105, 2018
952018
Mild innate immune activation overrides efficient nanoparticle‐mediated RNA delivery
MP Lokugamage, Z Gan, C Zurla, J Levin, FZ Islam, S Kalathoor, M Sato, ...
Advanced materials 32 (1), 1904905, 2020
882020
Testing thousands of nanoparticles in vivo using DNA barcodes
MP Lokugamage, CD Sago, JE Dahlman
Current Opinion in Biomedical Engineering 7, 1-8, 2018
672018
Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles
MZC Hatit, MP Lokugamage, CN Dobrowolski, K Paunovska, H Ni, ...
Nature nanotechnology 17 (3), 310-318, 2022
632022
Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo
H Ni, MZC Hatit, K Zhao, D Loughrey, MP Lokugamage, HE Peck, AD Cid, ...
Nature Communications 13 (1), 4766, 2022
562022
Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands
Z Gan, MP Lokugamage, MZC Hatit, D Loughrey, K Paunovska, M Sato, ...
Bioengineering & translational medicine 5 (3), e10161, 2020
462020
Modifying a commonly expressed endocytic receptor retargets nanoparticles in vivo
CD Sago, MP Lokugamage, GN Lando, N Djeddar, NN Shah, C Syed, ...
Nano letters 18 (12), 7590-7600, 2018
422018
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery
C Dobrowolski, K Paunovska, E Schrader Echeverri, D Loughrey, ...
Nature Nanotechnology 17 (8), 871-879, 2022
402022
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver
CD Sago, MP Lokugamage, D Loughrey, KE Lindsay, R Hincapie, ...
Nature biomedical engineering 6 (2), 157-167, 2022
372022
Cell subtypes within the liver microenvironment differentially interact with lipid nanoparticles
CD Sago, BR Krupczak, MP Lokugamage, Z Gan, JE Dahlman
Cellular and Molecular Bioengineering 12, 389-397, 2019
362019
Therapeutic RNA delivery for COVID and other diseases
C Dobrowolski, K Paunovska, MZC Hatit, MP Lokugamage, JE Dahlman
Advanced healthcare materials 10 (15), 2002022, 2021
342021
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo
A Radmand, MP Lokugamage, H Kim, C Dobrowolski, R Zenhausern, ...
Nano letters 23 (3), 993-1002, 2023
232023
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery
MZC Hatit, CN Dobrowolski, MP Lokugamage, D Loughrey, H Ni, C Zurla, ...
Nature Chemistry 15 (4), 508-515, 2023
222023
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo
SG Huayamares, MP Lokugamage, R Rab, AJDS Sanchez, H Kim, ...
Journal of Controlled Release 357, 394-403, 2023
212023
Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery
AJDS Sanchez, K Zhao, SG Huayamares, MZC Hatit, MP Lokugamage, ...
Journal of Controlled Release 353, 270-277, 2023
202023
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