Jeffrey James Lochhead
Jeffrey James Lochhead
Research Assistant Professor, University of Arizona
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Cited by
Cited by
Intranasal delivery of biologics to the central nervous system
JJ Lochhead, RG Thorne
Advanced drug delivery reviews 64 (7), 614-628, 2012
Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results
DL Sparks, MN Sabbagh, DJ Connor, J Lopez, LJ Launer, P Browne, ...
Archives of neurology 62 (5), 753-757, 2005
Oxidative stress increases blood–brain barrier permeability and induces alterations in occludin during hypoxia–reoxygenation
JJ Lochhead, G McCaffrey, CE Quigley, J Finch, KM DeMarco, N Nametz, ...
Journal of Cerebral Blood Flow & Metabolism 30 (9), 1625-1636, 2010
Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration
JJ Lochhead, DJ Wolak, ME Pizzo, RG Thorne
Journal of Cerebral Blood Flow & Metabolism 35 (3), 371-381, 2015
Structure, function, and regulation of the blood-brain barrier tight junction in central nervous system disorders
JJ Lochhead, J Yang, PT Ronaldson, TP Davis
Frontiers in physiology 11, 558491, 2020
Distribution of insulin in trigeminal nerve and brain after intranasal administration
JJ Lochhead, KL Kellohen, PT Ronaldson, TP Davis
Scientific reports 9 (1), 2621, 2019
Occludin oligomeric assemblies at tight junctions of the blood–brain barrier are altered by hypoxia and reoxygenation stress
G McCaffrey, CL Willis, WD Staatz, N Nametz, CA Quigley, S Hom, ...
Journal of neurochemistry 110 (1), 58-71, 2009
Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD
DL Sparks, MN Sabbagh, DJ Connor, J Lopez, LJ Launer, S Petanceska, ...
Current Alzheimer Research 2 (3), 343-353, 2005
Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery
NN Kumar, JJ Lochhead, ME Pizzo, G Nehra, S Boroumand, G Greene, ...
Journal of controlled release 286, 467-484, 2018
Hypoxic stress and inflammatory pain disrupt blood-brain barrier tight junctions: implications for drug delivery to the central nervous system
JJ Lochhead, PT Ronaldson, TP Davis
The AAPS Journal 19, 910-920, 2017
Perivascular and perineural pathways involved in brain delivery and distribution of drugs after intranasal administration
JJ Lochhead, TP Davis
Pharmaceutics 11 (11), 598, 2019
Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain
JJ Lochhead, G McCaffrey, L Sanchez-Covarrubias, JD Finch, ...
American Journal of Physiology-Heart and Circulatory Physiology 302 (3 …, 2012
Cholesterol, copper and Aβ in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT)
DL Sparks, S Petanceska, M Sabbagh, D Connor, H Soares, C Adler, ...
Current Alzheimer Research 2 (5), 527-539, 2005
Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid β (Aβ) in rabbit brain
DL Sparks, J Lochhead, D Horstman, T Wagoner, T Martin
Journal of Alzheimer's Disease 4 (6), 523-529, 2002
Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery
NN Kumar, M Gautam, JJ Lochhead, DJ Wolak, V Ithapu, V Singh, ...
Scientific reports 6 (1), 31732, 2016
Intranasal drug delivery to the brain
JJ Lochhead, RG Thorne
Drug delivery to the brain: physiological concepts, methodologies and …, 2013
Cholesterol modifies classical conditioning of the rabbit (Oryctolagus cuniculus) nictitating membrane response.
BG Schreurs, CA Smith-Bell, J Lochhead, DL Sparks
Behavioral Neuroscience 117 (6), 1220, 2003
Benefit of atorvastatin in the treatment of Alzheimer disease
DL Sparks, D Connor, J Lopez, L Launer, S Petanceska, L Baxter, ...
Neurobiol Aging 25 (Suppl 1), S24, 2004
βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling
EA Kwak, CC Pan, A Ramonett, S Kumar, P Cruz-Flores, T Ahmed, ...
Nature communications 13 (1), 1326, 2022
Regulation of blood-brain barrier transporters by transforming growth factor-β/Activin Receptor-Like Kinase 1 Signaling: relevance to the brain disposition of 3-hydroxy-3 …
RD Betterton, W Abdullahi, EI Williams, JJ Lochhead, H Brzica, J Stanton, ...
Drug Metabolism and Disposition 50 (7), 942-956, 2022
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