A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera C James, V Ugo, JP Le Couédic, J Staerk, F Delhommeau, C Lacout, ... nature 434 (7037), 1144-1148, 2005 | 4547 | 2005 |
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types M Wernig, CJ Lengner, J Hanna, MA Lodato, E Steine, R Foreman, ... Nature biotechnology 26 (8), 916-924, 2008 | 577 | 2008 |
Reprogramming of human peripheral blood cells to induced pluripotent stem cells J Staerk, MM Dawlaty, Q Gao, D Maetzel, J Hanna, CA Sommer, ... Cell stem cell 7 (1), 20-24, 2010 | 540 | 2010 |
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4 CA Lyssiotis, RK Foreman, J Staerk, M Garcia, D Mathur, S Markoulaki, ... Proceedings of the National Academy of Sciences 106 (22), 8912-8917, 2009 | 495 | 2009 |
Metastable pluripotent states in NOD-mouse-derived ESCs J Hanna, S Markoulaki, M Mitalipova, AW Cheng, JP Cassady, J Staerk, ... Cell stem cell 4 (6), 513-524, 2009 | 408 | 2009 |
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor J Staerk, A Kallin, JB Demoulin, W Vainchenker, SN Constantinescu Journal of Biological Chemistry 280 (51), 41893-41899, 2005 | 268 | 2005 |
Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer N Seubert, Y Royer, J Staerk, KF Kubatzky, V Moucadel, S Krishnakumar, ... Molecular cell 12 (5), 1239-1250, 2003 | 234 | 2003 |
Janus kinases affect thrombopoietin receptor cell surface localization and stability Y Royer, J Staerk, M Costuleanu, PJ Courtoy, SN Constantinescu Journal of Biological Chemistry 280 (29), 27251-27261, 2005 | 220 | 2005 |
An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor J Staerk, C Lacout, T Sato, SO Smith, W Vainchenker, SN Constantinescu Blood 107 (5), 1864-1871, 2006 | 195 | 2006 |
The myeloproliferative disorder–associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3 MB Hookham, J Elliott, Y Suessmuth, J Staerk, AC Ward, W Vainchenker, ... Blood, The Journal of the American Society of Hematology 109 (11), 4924-4929, 2007 | 168 | 2007 |
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress M Luhr, ML Torgersen, P Szalai, A Hashim, A Brech, J Staerk, N Engedal Journal of Biological Chemistry 294 (20), 8197-8217, 2019 | 134 | 2019 |
Orientation‐specific signalling by thrombopoietin receptor dimers J Staerk, JP Defour, C Pecquet, E Leroy, H Antoine‐Poirel, I Brett, M Itaya, ... The EMBO journal 30 (21), 4398-4413, 2011 | 96 | 2011 |
Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor C Pecquet, J Staerk, R Chaligné, V Goss, KA Lee, X Zhang, J Rush, ... Blood, The Journal of the American Society of Hematology 115 (5), 1037-1048, 2010 | 96 | 2010 |
Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor α homodimers T Hornakova, J Staerk, Y Royer, E Flex, M Tartaglia, SN Constantinescu, ... Journal of biological chemistry 284 (11), 6773-6781, 2009 | 86 | 2009 |
Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2 A Dusa, J Staerk, J Elliott, C Pecquet, HA Poirel, JA Johnston, ... Journal of biological chemistry 283 (19), 12941-12948, 2008 | 77 | 2008 |
Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes C Pecquet, CC Diaconu, J Staerk, M Girardot, C Marty, Y Royer, ... Blood, The Journal of the American Society of Hematology 119 (20), 4625-4635, 2012 | 62 | 2012 |
Pan‐Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells J Staerk, CA Lyssiotis, LA Medeiro, M Bollong, RK Foreman, S Zhu, ... Angewandte Chemie International Edition 50 (25), 5734-5736, 2011 | 58 | 2011 |
JAK2, the JAK2 V617F mutant and cytokine receptors J Staerk, A Kallin, Y Royer, CC Diaconu, A Dusa, JB Demoulin, ... Pathologie Biologie 55 (2), 88-91, 2007 | 46 | 2007 |
The ubiquitin-mediated degradation of Jak1 modulates osteoclastogenesis by limiting interferon-β–induced inhibitory signaling Y Lee, SW Hyung, HJ Jung, HJ Kim, J Staerk, SN Constantinescu, ... Blood, The Journal of the American Society of Hematology 111 (2), 885-893, 2008 | 45 | 2008 |
His499 regulates dimerization and prevents oncogenic activation by asparagine mutations of the human thrombopoietin receptor E Leroy, JP Defour, T Sato, S Dass, V Gryshkova, MM Shwe, J Staerk, ... Journal of Biological Chemistry 291 (6), 2974-2987, 2016 | 36 | 2016 |