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Mark Lynch, PhD.
Mark Lynch, PhD.
Verified email at bms.com
Title
Cited by
Cited by
Year
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
SM Wilhelm, C Carter, LY Tang, D Wilkie, A McNabola, H Rong, C Chen, ...
Cancer research 64 (19), 7099-7109, 2004
51722004
Nivolumab for recurrent squamous-cell carcinoma of the head and neck
RL Ferris, G Blumenschein Jr, J Fayette, J Guigay, AD Colevas, L Licitra, ...
New England Journal of Medicine 375 (19), 1856-1867, 2016
45572016
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
S Wilhelm, C Carter, M Lynch, T Lowinger, J Dumas, RA Smith, ...
Nature reviews Drug discovery 5 (10), 835-844, 2006
20582006
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
L Liu, Y Cao, C Chen, X Zhang, A McNabola, D Wilkie, S Wilhelm, ...
Cancer research 66 (24), 11851-11858, 2006
17772006
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
SM Wilhelm, L Adnane, P Newell, A Villanueva, JM Llovet, M Lynch
Molecular cancer therapeutics 7 (10), 3129-3140, 2008
16462008
Regorafenib (BAY 73‐4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
SM Wilhelm, J Dumas, L Adnane, M Lynch, CA Carter, G Schütz, ...
International journal of cancer 129 (1), 245-255, 2011
13352011
Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
YS Chang, J Adnane, PA Trail, J Levy, A Henderson, D Xue, E Bortolon, ...
Cancer chemotherapy and pharmacology 59, 561-574, 2007
8402007
Nivolumab vs investigator’s choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by …
RL Ferris, G Blumenschein Jr, J Fayette, J Guigay, AD Colevas, L Licitra, ...
Oral oncology 81, 45-51, 2018
7272018
Nivolumab versus standard, single-agent therapy of investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141): health-related …
KJ Harrington, RL Ferris, G Blumenschein, AD Colevas, J Fayette, ...
The Lancet Oncology 18 (8), 1104-1115, 2017
3992017
Biological characterization and oncogene expression in human colorectal carcinoma cell lines
DL Trainer, T Kline, FL McCabe, LF Faucette, J Feild, M Chaikin, ...
International journal of cancer 41 (2), 287-296, 1988
2581988
Randomized phase 2 study: elotuzumab plus bortezomib/dexamethasone vs bortezomib/dexamethasone for relapsed/refractory MM
A Jakubowiak, M Offidani, B Pégourie, J De La Rubia, L Garderet, K Laribi, ...
Blood, The Journal of the American Society of Hematology 127 (23), 2833-2840, 2016
2332016
Antitumor activity of sorafenib in FLT3-driven leukemic cells
D Auclair, D Miller, V Yatsula, W Pickett, C Carter, Y Chang, X Zhang, ...
Leukemia 21 (3), 439-445, 2007
1982007
A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins
A Ryan, M Lynch, SM Smith, S Amu, HJ Nel, CE McCoy, JK Dowling, ...
PLoS pathogens 7 (6), e1002076, 2011
1962011
Biotic interactions and global change
M Lynch, R Lande, PM Kareiva, JG Kingsolver, RB Huey
by J. Kingslover P. Kareiva and R. Huey. Sinauer, Sunderland, MA, 234-250, 1993
1451993
Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor
WC Rose, FYF Lee, CR Fairchild, M Lynch, T Monticello, RA Kramer, ...
Cancer research 61 (20), 7507-7517, 2001
1402001
Nivolumab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: efficacy and safety in CheckMate 141 by prior cetuximab use
RL Ferris, L Licitra, J Fayette, C Even, G Blumenschein Jr, KJ Harrington, ...
Clinical Cancer Research 25 (17), 5221-5230, 2019
1382019
A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
SM Wilhelm, J Dumas, L Adnane, M Lynch, CA Carter, G Schütz, ...
Int. J. Cancer 129 (1), 245-255, 2011
1282011
A randomized, open-label, Phase III clinical trial of nivolumab vs. therapy of investigator’s choice in recurrent squamous cell carcinoma of the head and neck: A subanalysis of …
N Kiyota, Y Hasegawa, S Takahashi, T Yokota, CJ Yen, S Iwae, Y Shimizu, ...
Oral oncology 73, 138-146, 2017
1082017
Regulation by estrogen through the 5′-flanking region of the transforming growth factor α gene
T Saeki, A Cristiano, MJ Lynch, M Brattain, N Kim, N Normanno, ...
Molecular Endocrinology 5 (12), 1955-1963, 1991
1051991
CheckMate 141: 1‐year update and subgroup analysis of nivolumab as first‐line therapy in patients with recurrent/metastatic head and neck cancer
ML Gillison, G Blumenschein Jr, J Fayette, J Guigay, AD Colevas, L Licitra, ...
The oncologist 23 (9), 1079-1082, 2018
101*2018
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