Timothy R. Rudd
Timothy R. Rudd
Medicines & Healthcare products Regulatory Agency
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Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin
CJ Mycroft-West, D Su, I Pagani, TR Rudd, S Elli, NS Gandhi, ...
Thrombosis and haemostasis 120 (12), 1700-1715, 2020
Heparan sulfate and heparin interactions with proteins
MCZ Meneghetti, AJ Hughes, TR Rudd, HB Nader, AK Powell, EA Yates, ...
Journal of the Royal Society Interface 12 (110), 20150589, 2015
N-glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co-receptor binding
L Duchesne, B Tissot, TR Rudd, A Dell, DG Fernig
Journal of Biological Chemistry 281 (37), 27178-27189, 2006
Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity
R Xu, A Ori, TR Rudd, KA Uniewicz, YA Ahmed, SE Guimond, ...
Journal of Biological Chemistry 287 (47), 40061-40073, 2012
Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives
TR Rudd, SE Guimond, MA Skidmore, L Duchesne, M Guerrini, G Torri, ...
Glycobiology 17 (9), 983-993, 2007
Real-time monitoring of the development and stability of biofilms of Streptococcus mutans using the quartz crystal microbalance with dissipation monitoring
AL Schofield, TR Rudd, DS Martin, DG Fernig, C Edwards
Biosensors and Bioelectronics 23 (3), 407-413, 2007
New applications of heparin and other glycosaminoglycans
M Lima, T Rudd, E Yates
Molecules 22 (5), 749, 2017
An unusual antithrombin-binding heparin octasaccharide with an additional 3-O-sulfated glucosamine in the active pentasaccharide sequence
M Guerrini, S Elli, P Mourier, TR Rudd, D Gaudesi, B Casu, C Boudier, ...
Biochemical Journal 449 (2), 343-351, 2013
The conformation and structure of GAGs: recent progress and perspectives
TR Rudd, MA Skidmore, M Guerrini, M Hricovini, AK Powell, G Siligardi, ...
Current opinion in structural biology 20 (5), 567-574, 2010
CDApps: integrated software for experimental planning and data processing at beamline B23, Diamond Light Source
R Hussain, K Benning, T Javorfi, E Longo, TR Rudd, B Pulford, G Siligardi
Journal of synchrotron radiation 22 (2), 465-468, 2015
Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra
TR Rudd, MA Skidmore, SE Guimond, C Cosentino, G Torri, DG Fernig, ...
Glycobiology 19 (1), 52-67, 2009
Human (α2→ 6) and avian (α2→ 3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution
GL Sassaki, S Elli, TR Rudd, E Macchi, EA Yates, A Naggi, Z Shriver, ...
Biochemistry 52 (41), 7217-7230, 2013
Atomic details of the interactions of glycosaminoglycans with amyloid-β fibrils
KL Stewart, E Hughes, EA Yates, GR Akien, TY Huang, MA Lima, ...
Journal of the American Chemical Society 138 (27), 8328-8331, 2016
Site-specific interactions of copper (II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques
TR Rudd, MA Skidmore, SE Guimond, M Guerrini, C Cosentino, R Edge, ...
Carbohydrate research 343 (12), 2184-2193, 2008
A highly efficient tree structure for the biosynthesis of heparan sulfate accounts for the commonly observed disaccharides and suggests a mechanism for domain synthesis
TR Rudd, EA Yates
Molecular BioSystems 8 (5), 1499-1506, 2012
The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation
MA Skidmore, SE Guimond, TR Rudd, DG Fernig, JE Turnbull, EA Yates
Connective tissue research 49 (3-4), 140-144, 2008
Differentiation of generic enoxaparins marketed in the United States by employing NMR and multivariate analysis
M Guerrini, TR Rudd, L Mauri, E Macchi, J Fareed, EA Yates, A Naggi, ...
Analytical chemistry 87 (16), 8275-8283, 2015
Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships
TR Rudd, KA Uniewicz, A Ori, SE Guimond, MA Skidmore, D Gaudesi, ...
Organic & biomolecular chemistry 8 (23), 5390-5397, 2010
The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis
TR Rudd, MD Preston, EA Yates
Molecular BioSystems 13 (5), 852-865, 2017
Inhibition of influenza H5N1 invasion by modified heparin derivatives
MA Skidmore, A Kajaste-Rudnitski, NM Wells, SE Guimond, TR Rudd, ...
MedChemComm 6 (4), 640-646, 2015
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