Donita Africander
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Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception
D Africander, N Verhoog, JP Hapgood
Steroids 76 (7), 636-652, 2011
11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer?
KH Storbeck, LM Bloem, D Africander, L Schloms, P Swart, AC Swart
Molecular and cellular endocrinology 377 (1-2), 135-146, 2013
Potency of progestogens used in hormonal therapy: toward understanding differential actions
JP Hapgood, D Africander, R Louw, RM Ray, JM Rohwer
The Journal of steroid biochemistry and molecular biology 142, 39-47, 2014
11-Ketotestosterone and 11-ketodihydrotestosterone in castration resistant prostate cancer: potent androgens which can no longer be ignored
E Pretorius, DJ Africander, M Vlok, MS Perkins, J Quanson, KH Storbeck
PloS one 11 (7), e0159867, 2016
Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound a
S Robertson, F Allie-Reid, WV Berghe, K Visser, A Binder, D Africander, ...
Journal of Biological Chemistry 285 (11), 8061-8075, 2010
Not all progestins are the same: implications for usage
JP Hapgood, D Koubovec, A Louw, D Africander
Trends in pharmacological sciences 25 (11), 554-557, 2004
The injectable-only contraceptive medroxyprogesterone acetate, unlike norethisterone acetate and progesterone, regulates inflammatory genes in endocervical cells via the …
Y Govender, C Avenant, NJD Verhoog, RM Ray, NJ Grantham, ...
PloS one 9 (5), e96497, 2014
Differential regulation of endogenous pro-inflammatory cytokine genes by medroxyprogesterone acetate and norethisterone acetate in cell lines of the female genital tract
D Africander, R Louw, N Verhoog, D Noeth, JP Hapgood
Contraception 84 (4), 423-435, 2011
A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A)
DJ Africander, KH Storbeck, JP Hapgood
The Journal of steroid biochemistry and molecular biology 143, 404-415, 2014
Comparing the androgenic and estrogenic properties of progestins used in contraception and hormone therapy
R Louw-du Toit, MS Perkins, JP Hapgood, D Africander
Biochemical and biophysical research communications 491 (1), 140-146, 2017
Investigating the anti-mineralocorticoid properties of synthetic progestins used in hormone therapy
D Africander, R Louw, JP Hapgood
Biochemical and biophysical research communications 433 (3), 305-310, 2013
Medroxyprogesterone acetate differentially regulates interleukin (IL)-12 and IL-10 in a human ectocervical epithelial cell line in a glucocorticoid receptor (GR)-dependent manner
R Louw-du Toit, JP Hapgood, D Africander
Journal of Biological Chemistry 289 (45), 31136-31149, 2014
Steroid metabolism in breast cancer: Where are we and what are we missing?
D Africander, KH Storbeck
Molecular and Cellular Endocrinology 466, 86-97, 2018
A comparative characterization of estrogens used in hormone therapy via estrogen receptor (ER)-α and-β
MS Perkins, R Louw-du Toit, D Africander
The Journal of Steroid Biochemistry and Molecular Biology 174, 27-39, 2017
16α-hydroxyprogesterone: origin, biosynthesis and receptor interaction
KH Storbeck, P Swart, D Africander, R Conradie, R Louw, AC Swart
Molecular and cellular endocrinology 336 (1-2), 92-101, 2011
Hormone therapy and breast cancer: emerging steroid receptor mechanisms
MS Perkins, R Louw-du Toit, D Africander
Journal of Molecular Endocrinology 61 (4), R133-R160, 2018
Progestins used in endocrine therapy and the implications for the biosynthesis and metabolism of endogenous steroid hormones
R Louw-du Toit, KH Storbeck, M Cartwright, A Cabral, D Africander
Molecular and cellular endocrinology 441, 31-45, 2017
Sutherlandia frutescens modulates adrenal hormone biosynthesis, acts as a selective glucocorticoid receptor agonist (SEGRA) and displays anti-mineralocorticoid properties
CA Sergeant, D Africander, P Swart, AC Swart
Journal of Ethnopharmacology 202, 290-301, 2017
Fourth-generation progestins inhibit 3β-hydroxysteroid dehydrogenase type 2 and modulate the biosynthesis of endogenous steroids
R Louw-du Toit, MS Perkins, JL Snoep, KH Storbeck, D Africander
PloS one 11 (10), e0164170, 2016
11-oxygenated estrogens are a novel class of human estrogens but do not contribute to the circulating estrogen pool
L Barnard, L Schiffer, R Louw du-Toit, JA Tamblyn, S Chen, D Africander, ...
Endocrinology 162 (3), bqaa231, 2021
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