Kelly Chibale
Kelly Chibale
Unknown affiliation
Verified email at uct.ac.za
Title
Cited by
Cited by
Year
Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against Plasmodium falciparum, Trypanosoma brucei, and …
DC Greenbaum, Z Mackey, E Hansell, P Doyle, J Gut, CR Caffrey, ...
Journal of medicinal chemistry 47 (12), 3212-3219, 2004
3112004
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
EM Guantai, K Ncokazi, TJ Egan, J Gut, PJ Rosenthal, PJ Smith, ...
Bioorganic & medicinal chemistry 18 (23), 8243-8256, 2010
2042010
Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents
K Chibale, M Visser, D van Schalkwyk, PJ Smith, A Saravanamuthu, ...
Tetrahedron 59 (13), 2289-2296, 2003
2002003
Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives
I Chiyanzu, C Clarkson, PJ Smith, J Lehman, J Gut, PJ Rosenthal, ...
Bioorganic & medicinal chemistry 13 (9), 3249-3261, 2005
1812005
Synthesis, antimalarial and antitubercular activity of acetylenic chalcones
RH Hans, EM Guantai, C Lategan, PJ Smith, B Wan, SG Franzblau, J Gut, ...
Bioorganic & medicinal chemistry letters 20 (3), 942-944, 2010
1802010
The state of the art in anti-malarial drug discovery and development
J N Burrows, K Chibale, T NC Wells
Current topics in medicinal chemistry 11 (10), 1226-1254, 2011
1772011
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain
I Chiyanzu, E Hansell, J Gut, PJ Rosenthal, JH McKerrow, K Chibale
Bioorganic & medicinal chemistry letters 13 (20), 3527-3530, 2003
1612003
Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery
M Hohman, K Gregory, K Chibale, PJ Smith, S Ekins, B Bunin
Drug discovery today 14 (5-6), 261-270, 2009
1412009
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ...
Science translational medicine 9 (387), 2017
1362017
3, 5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential
Y Younis, F Douelle, TS Feng, DG Cabrera, CL Manach, AT Nchinda, ...
Journal of medicinal chemistry 55 (7), 3479-3487, 2012
1282012
The role of natural products in drug discovery and development against neglected tropical diseases
PM Cheuka, G Mayoka, P Mutai, K Chibale
Molecules 22 (1), 58, 2017
1172017
Synthesis and antiplasmodial activity in vitro of new ferrocene–chloroquine analogues
P Beagley, MAL Blackie, K Chibale, C Clarkson, R Meijboom, JR Moss, ...
Dalton Transactions, 3046-3051, 2003
1162003
Design, synthesis and biological evaluation of carbohydrate-based mimetics of cRGDFV
KC Nicolaou, JI Trujillo, K Chibale
Tetrahedron 53 (26), 8751-8778, 1997
1141997
Cyclopalladated complexes containing tridentate thiosemicarbazone ligands of biological significance: Synthesis, structure and antimalarial activity
P Chellan, S Nasser, L Vivas, K Chibale, GS Smith
Journal of organometallic chemistry 695 (19-20), 2225-2232, 2010
1062010
Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine
K Chibale, H Haupt, H Kendrick, V Yardley, A Saravanamuthu, ...
Bioorganic & medicinal chemistry letters 11 (19), 2655-2657, 2001
1052001
New amine and urea analogs of ferrochloroquine: synthesis, antimalarial activity in vitro and electrochemical studies
K Chibale, JR Moss, M Blackie, D van Schalkwyk, PJ Smith
Tetrahedron Letters 41 (32), 6231-6235, 2000
1032000
Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis
M Njoroge, NM Njuguna, P Mutai, DSB Ongarora, PW Smith, K Chibale
Chemical reviews 114 (22), 11138-11163, 2014
1022014
Design, synthesis and biological evaluation of nonpeptide integrin antagonists
KC Nicolaou, JI Trujillo, B Jandeleit, K Chibale, M Rosenfeld, ...
Bioorganic & medicinal chemistry 6 (8), 1185-1208, 1998
1021998
Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio) semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine …
A Chipeleme, J Gut, PJ Rosenthal, K Chibale
Bioorganic & medicinal chemistry 15 (1), 273-282, 2007
982007
Synthetic medicinal chemistry of selected antimalarial natural products
V Kumar, A Mahajan, K Chibale
Bioorganic & medicinal chemistry 17 (6), 2236-2275, 2009
952009
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