| Kinase inhibitors modulate huntingtin cell localization and toxicity RS Atwal, CR Desmond, N Caron, T Maiuri, J Xia, S Sipione, R Truant Nature chemical biology 7 (7), 453-460, 2011 | 215 | 2011 |
| Huntington disease NS Caron, GEB Wright, MR Hayden GeneReviews®[Internet], 2020 | 191 | 2020 |
| Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease L Munsie, N Caron, RS Atwal, I Marsden, EJ Wild, JR Bamburg, SJ Tabrizi, ... Human molecular genetics 20 (10), 1937-1951, 2011 | 165 | 2011 |
| Therapeutic approaches to Huntington disease: from the bench to the clinic NS Caron, ER Dorsey, MR Hayden Nature Reviews Drug Discovery 17 (10), 729-750, 2018 | 158 | 2018 |
| Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin NS Caron, CR Desmond, J Xia, R Truant Proceedings of the National Academy of Sciences 110 (36), 14610-14615, 2013 | 158 | 2013 |
| Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease AL Southwell, HB Kordasiewicz, D Langbehn, NH Skotte, MP Parsons, ... Science translational medicine 10 (461), eaar3959, 2018 | 122 | 2018 |
| Huntingtin haplotypes provide prioritized target panels for allele-specific silencing in Huntington disease patients of European ancestry C Kay, JA Collins, NH Skotte, AL Southwell, SC Warby, NS Caron, ... Molecular Therapy 23 (11), 1759-1771, 2015 | 115 | 2015 |
| Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression AL Southwell, SEP Smith, TR Davis, NS Caron, EB Villanueva, Y Xie, ... Scientific reports 5 (1), 12166, 2015 | 110 | 2015 |
| Using FLIM-FRET to measure conformational changes of transglutaminase type 2 in live cells NS Caron, LN Munsie, JW Keillor, R Truant Public Library of Science 7 (8), e44159, 2012 | 98 | 2012 |
| Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease C Ferrari Bardile, M Garcia-Miralles, NS Caron, NA Rayan, SR Langley, ... Proceedings of the National Academy of Sciences 116 (19), 9622-9627, 2019 | 97 | 2019 |
| Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease NS Caron, AL Southwell, CC Brouwers, LD Cengio, Y Xie, HF Black, ... Nucleic acids research 48 (1), 36-54, 2020 | 74 | 2020 |
| Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease M Garcia-Miralles, X Hong, LJ Tan, NS Caron, Y Huang, XV To, RY Lin, ... Scientific reports 6 (1), 31652, 2016 | 74 | 2016 |
| Lifeact cannot visualize some forms of stress-induced twisted F-actin LN Munsie, N Caron, CR Desmond, R Truant Nature methods 6 (5), 317-317, 2009 | 68 | 2009 |
| Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies GEB Wright, HF Black, JA Collins, T Gall-Duncan, NS Caron, CE Pearson, ... The Lancet Neurology 19 (11), 930-939, 2020 | 62 | 2020 |
| Mutant huntingtin is cleared from the brain via active mechanisms in Huntington disease NS Caron, R Banos, C Yanick, AE Aly, LM Byrne, ED Smith, Y Xie, ... Journal of Neuroscience 41 (4), 780-796, 2021 | 60 | 2021 |
| Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease DE Ehrnhoefer, DDO Martin, ME Schmidt, X Qiu, S Ladha, NS Caron, ... Acta neuropathologica communications 6, 1-16, 2018 | 60 | 2018 |
| Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range HF Black, GEB Wright, JA Collins, N Caron, C Kay, Q Xia, L Arning, ... Genetics in Medicine 22 (12), 2108-2113, 2020 | 47 | 2020 |
| Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions NS Caron, CL Hung, RS Atwal, R Truant Human molecular genetics 23 (9), 2324-2338, 2014 | 42 | 2014 |
| GeneReviews® NS Caron, GEB Wright, MR Hayden, MP Adam, HH Ardinger, RA Pagon, ... The National Center for Biotechnology Information, Seattle, WA, 2020 | 37 | 2020 |
| Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons DE Ehrnhoefer, NS Caron, Y Deng, X Qiu, M Tsang, MR Hayden Experimental neurology 283, 121-128, 2016 | 33 | 2016 |
