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David Holtzman
David Holtzman
Verified email at neuro.wustl.edu
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Year
The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic …
MS Albert, ST DeKosky, D Dickson, B Dubois, HH Feldman, NC Fox, ...
Focus 11 (1), 96-106, 2013
120012013
NIA‐AA research framework: toward a biological definition of Alzheimer's disease
CR Jack Jr, DA Bennett, K Blennow, MC Carrillo, B Dunn, SB Haeberlein, ...
Alzheimer's & dementia 14 (4), 535-562, 2018
85382018
Inflammation and Alzheimer’s disease
H Akiyama, S Barger, S Barnum, B Bradt, J Bauer, GM Cole, NR Cooper, ...
Neurobiology of aging 21 (3), 383-421, 2000
58262000
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
RJ Bateman, C Xiong, TLS Benzinger, AM Fagan, A Goate, NC Fox, ...
New England Journal of Medicine 367 (9), 795-804, 2012
43132012
Alzheimer disease: an update on pathobiology and treatment strategies
JM Long, DM Holtzman
Cell 179 (2), 312-339, 2019
25742019
The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases
S Krasemann, C Madore, R Cialic, C Baufeld, N Calcagno, R El Fatimy, ...
Immunity 47 (3), 566-581. e9, 2017
23272017
National Institute of Neurological Disorders and Stroke–Canadian stroke network vascular cognitive impairment harmonization standards
V Hachinski, C Iadecola, RC Petersen, MM Breteler, DL Nyenhuis, ...
Stroke 37 (9), 2220-2241, 2006
23042006
The role of apolipoprotein E in Alzheimer's disease
J Kim, JM Basak, DM Holtzman
Neuron 63 (3), 287-303, 2009
20232009
Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria
B Dubois, H Hampel, HH Feldman, P Scheltens, P Aisen, S Andrieu, ...
Alzheimer's & Dementia 12 (3), 292-323, 2016
19872016
Alzheimer’s disease: the challenge of the second century
DM Holtzman, JC Morris, AM Goate
Science translational medicine 3 (77), 77sr1-77sr1, 2011
18062011
Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier
M Shibata, S Yamada, SR Kumar, M Calero, J Bading, B Frangione, ...
The Journal of clinical investigation 106 (12), 1489-1499, 2000
17952000
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
RB DeMattos, KR Bales, DJ Cummins, JC Dodart, SM Paul, DM Holtzman
Proceedings of the National Academy of Sciences 98 (15), 8850-8855, 2001
17832001
Alzheimer disease
DS Knopman, H Amieva, RC Petersen, G Chételat, DM Holtzman, ...
Nature reviews Disease primers 7 (1), 33, 2021
17482021
Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle
JE Kang, MM Lim, RJ Bateman, JJ Lee, LP Smyth, JR Cirrito, N Fujiki, ...
Science 326 (5955), 1005-1007, 2009
17392009
TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model
Y Wang, M Cella, K Mallinson, JD Ulrich, KL Young, ML Robinette, ...
Cell 160 (6), 1061-1071, 2015
16672015
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans
AM Fagan, MA Mintun, RH Mach, SY Lee, CS Dence, AR Shah, ...
Annals of neurology 59 (3), 512-519, 2006
15442006
Synaptic activity regulates interstitial fluid amyloid-β levels in vivo
JR Cirrito, KA Yamada, MB Finn, RS Sloviter, KR Bales, PC May, ...
Neuron 48 (6), 913-922, 2005
14802005
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
JM Castellano, J Kim, FR Stewart, H Jiang, RB DeMattos, BW Patterson, ...
Science translational medicine 3 (89), 89ra57-89ra57, 2011
14732011
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
RD Bell, EA Winkler, I Singh, AP Sagare, R Deane, Z Wu, DM Holtzman, ...
Nature 485 (7399), 512-516, 2012
13702012
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
SE Arnold, Z Arvanitakis, SL Macauley-Rambach, AM Koenig, HY Wang, ...
Nature Reviews Neurology 14 (3), 168-181, 2018
13422018
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