Timothy J Egan
Timothy J Egan
Professor of Chemistry, University of Cape Town
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Quinoline anti-malarial drugs inhibit spontaneous formation of β-haematin (malaria pigment)
TJ Egan, DC Ross, PA Adams
FEBS letters 352 (1), 54-57, 1994
Structure− function relationships in aminoquinolines: effect of amino and chloro groups on quinoline− hematin complex formation, inhibition of β-hematin formation, and …
TJ Egan, R Hunter, CH Kaschula, HM Marques, A Misplon, J Walden
Journal of medicinal chemistry 43 (2), 283-291, 2000
Fate of haem iron in the malaria parasite Plasmodium falciparum.
TJ Egan, JM Combrinck, J Egan, GR Hearne, HM Marques, S Ntenteni, ...
Biochemical Journal 365 (Pt 2), 343, 2002
Structure− activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position
CH Kaschula, TJ Egan, R Hunter, N Basilico, S Parapini, D Taramelli, ...
Journal of Medicinal Chemistry 45 (16), 3531-3539, 2002
Haemozoin formation
TJ Egan
Molecular and biochemical parasitology 157 (2), 127-136, 2008
A colorimetric high-throughput β-hematin inhibition screening assay for use in the search for antimalarial compounds
KK Ncokazi, TJ Egan
Analytical biochemistry 338 (2), 306-319, 2005
Insights into the role of heme in the mechanism of action of antimalarials
JM Combrinck, TE Mabotha, KK Ncokazi, MA Ambele, D Taylor, PJ Smith, ...
ACS chemical biology 8 (1), 133-137, 2013
Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation
TJ Egan
Journal of inorganic biochemistry 102 (5-6), 1288-1299, 2008
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
EM Guantai, K Ncokazi, TJ Egan, J Gut, PJ Rosenthal, PJ Smith, ...
Bioorganic & medicinal chemistry 18 (23), 8243-8256, 2010
Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX
TJ Egan, WW Mavuso, DC Ross, HM Marques
Journal of inorganic biochemistry 68 (2), 137-145, 1997
The mechanism of β-hematin formation in acetate solution. Parallels between hemozoin formation and biomineralization processes
TJ Egan, WW Mavuso, KK Ncokazi
Biochemistry 40 (1), 204-213, 2001
The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance
F Dubar, TJ Egan, B Pradines, D Kuter, KK Ncokazi, D Forge, JF Paul, ...
ACS chemical biology 6 (3), 275-287, 2011
Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity
C Biot, D Taramelli, I Forfar-Bares, LA Maciejewski, M Boyce, ...
Molecular pharmaceutics 2 (3), 185-193, 2005
Speciation and structure of ferriprotoporphyrin IX in aqueous solution: spectroscopic and diffusion measurements demonstrate dimerization, but not μ-oxo dimer formation
KA de Villiers, CH Kaschula, TJ Egan, HM Marques
JBIC Journal of Biological Inorganic Chemistry 12, 101-117, 2007
Haemozoin (β-haematin) biomineralization occurs by self-assembly near the lipid/water interface
TJ Egan, JYJ Chen, KA de Villiers, TE Mabotha, KJ Naidoo, KK Ncokazi, ...
FEBS letters 580 (21), 5105-5110, 2006
Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator
T Hänscheid, TJ Egan, MP Grobusch
The Lancet infectious diseases 7 (10), 675-685, 2007
Standardization of the physicochemical parameters to assess in vitro the β-hematin inhibitory activity of antimalarial drugs
S Parapini, N Basilico, E Pasini, TJ Egan, P Olliaro, D Taramelli, D Monti
Experimental parasitology 96 (4), 249-256, 2000
The crystal structure of halofantrine–ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials
KA de Villiers, HM Marques, TJ Egan
Journal of inorganic biochemistry 102 (8), 1660-1667, 2008
Quinoline antimalarials decrease the rate of β-hematin formation
TJ Egan, KK Ncokazi
Journal of inorganic biochemistry 99 (7), 1532-1539, 2005
Interactions of quinoline antimalarials with hematin in solution
TJ Egan
Journal of inorganic biochemistry 100 (5-6), 916-926, 2006
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