Leo James
Leo James
MRC Laboratory of Molecular Biology
Verified email at mrc-lmb.cam.ac.uk
Cited by
Cited by
Antibody multispecificity mediated by conformational diversity
LC James, P Roversi, DS Tawfik
Science 299 (5611), 1362-1367, 2003
Conformational diversity and protein evolution–a 60-year-old hypothesis revisited
LC James, DS Tawfik
Trends in biochemical sciences 28 (7), 361-368, 2003
HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency
T Schaller, KE Ocwieja, J Rasaiyaah, AJ Price, TL Brady, SL Roth, S Hué, ...
PLoS pathogens 7 (12), e1002439, 2011
HIV-1 evades innate immune recognition through specific cofactor recruitment
J Rasaiyaah, CP Tan, AJ Fletcher, AJ Price, C Blondeau, L Hilditch, ...
Nature 503 (7476), 402-405, 2013
Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
DL Mallery, WA McEwan, SR Bidgood, GJ Towers, CM Johnson, ...
Proceedings of the National Academy of Sciences 107 (46), 19985-19990, 2010
Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function
LC James, AH Keeble, Z Khan, DA Rhodes, J Trowsdale
Proceedings of the National Academy of Sciences 104 (15), 6200-6205, 2007
A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex
LP Jackson, BT Kelly, AJ McCoy, T Gaffry, LC James, BM Collins, ...
Cell 141 (7), 1220-1229, 2010
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21
WA McEwan, JCH Tam, RE Watkinson, SR Bidgood, DL Mallery, ...
Nature immunology 14 (4), 327-336, 2013
HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2
KE Ocwieja, TL Brady, K Ronen, A Huegel, SL Roth, T Schaller, ...
PLoS pathogens 7 (3), e1001313, 2011
A method for the acute and rapid degradation of endogenous proteins
D Clift, WA McEwan, LI Labzin, V Konieczny, B Mogessie, LC James, ...
Cell 171 (7), 1692-1706. e18, 2017
CPSF6 defines a conserved capsid interface that modulates HIV-1 replication
AJ Price, AJ Fletcher, T Schaller, T Elliott, KE Lee, VN KewalRamani, ...
Public Library of Science 8 (8), e1002896, 2012
Cellular self-defense: how cell-autonomous immunity protects against pathogens
F Randow, JD MacMicking, LC James
Science 340 (6133), 701-706, 2013
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly
AJ Price, DA Jacques, WA McEwan, AJ Fletcher, S Essig, JW Chin, ...
PLoS pathogens 10 (10), e1004459, 2014
TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved
AH Keeble, Z Khan, A Forster, LC James
Proceedings of the National Academy of Sciences 105 (16), 6045-6050, 2008
The specificity of cross‐reactivity: promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness
LC James, DS Tawfik
Protein Science 12 (10), 2183-2193, 2003
Crystal structure of HEL4, a soluble, refoldable human VH single domain with a germ-line scaffold
L Jespers, O Schon, LC James, D Veprintsev, G Winter
Journal of molecular biology 337 (4), 893-903, 2004
Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70
SA Kemp, B Meng, IATM Ferriera, R Datir, WT Harvey, DA Collier, ...
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
DA Jacques, WA McEwan, L Hilditch, AJ Price, GJ Towers, LC James
Nature 536 (7616), 349-353, 2016
SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids
L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul, AP Carter, ...
Cell stem cell 27 (6), 951-961. e5, 2020
Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin
DA Rhodes, HC Chen, AJ Price, AH Keeble, MS Davey, LC James, ...
The Journal of Immunology 194 (5), 2390-2398, 2015
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