| Breaking the Integrin Hinge: A DEFINED STRUCTURAL CONSTRAINT REGULATES INTEGRIN SIGNALING (∗) PE Hughes, F Diaz-Gonzalez, L Leong, C Wu, JA McDonald, SJ Shattil, ... Journal of Biological Chemistry 271 (12), 6571-6574, 1996 | 757 | 1996 |
| Integrin signaling: roles for the cytoplasmic tails of αIIbβ3 in the tyrosine phosphorylation of pp125FAK L Leong, PE Hughes, MA Schwartz, MH Ginsberg, SJ Shattil Journal of Cell Science 108 (12), 3817-3825, 1995 | 89 | 1995 |
| Evaluation of the activated partial thromboplastin time assay for clinical monitoring of PEG ylated recombinant factor VIII (BAY 94‐9027) for haemophilia A JM Gu, P Ramsey, V Evans, L Tang, H Apeler, L Leong, JE Murphy, ... Haemophilia 20 (4), 593-600, 2014 | 78 | 2014 |
| β3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of αIIbβ3 and αvβ3 YP Chen, TE O'Toole, L Leong, BQ Liu, F Diaz-Gonzalez, MH Ginsberg Blood 86 (7), 2606-2615, 1995 | 72 | 1995 |
| Differential expression of N-and B-cadherin during lens development L Leong, AS Menko, GB Grunwald Investigative ophthalmology & visual science 41 (11), 3503-3510, 2000 | 47 | 2000 |
| Clot stability as a determinant of effective factor VIII replacement in hemophilia A L Leong, IN Chernysh, Y Xu, D Sim, C Nagaswami, Z de Lange, ... Research and practice in thrombosis and haemostasis 1 (2), 231-241, 2017 | 38 | 2017 |
| The thrombin high-affinity binding site on platelets is a negative regulator of thrombin-induced platelet activation. Structure-function studies using two mutant thrombins … L Leong, RA Henriksen, JC Kermode, SE Rittenhouse, PB Tracy Biochemistry 31 (9), 2567-2576, 1992 | 35 | 1992 |
| Factor VIII activity of BAY 94‐9027 is accurately measured with most commonly used assays: results from an international laboratory study N Church, L Leong, Y Katterle, HF Ulbrich, I Noerenberg, S Kitchen, ... Haemophilia 24 (5), 823-832, 2018 | 22 | 2018 |
| Distinct domains of αIIbβ3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an αIIbβ3 interacting peptide JM Derrick, SJ Shattil, M Poncz, RA Gruppo, KT Gartner Thrombosis and haemostasis 86 (09), 894-901, 2001 | 20 | 2001 |
| Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models L Leong, D Sim, C Patel, K Tran, P Liu, E Ho, T Thompson, PJ Kretschmer, ... Blood, The Journal of the American Society of Hematology 125 (2), 392-398, 2015 | 14 | 2015 |
| Fragmentation of DNA E Friedlander, L Leong US Patent App. 10/665,916, 2004 | 12 | 2004 |
| alpha-Thrombin-induced human platelet activation results solely from formation of a specific enzyme-substrate complex. KL Hayes, L Leong, RA Henriksen, BA Bouchard, L Ouellette, WR Church, ... Journal of Biological Chemistry 269 (46), 28606-28612, 1994 | 12 | 1994 |
| Evidence from site-directed mutagenesis that the cytoplasmic domain of the β3 subunit influences the conformational state of the αvβ3 integrin ectodomain E Schaffner-Reckinger, NHC Brons, N Kieffer Thrombosis and haemostasis 85 (04), 716-723, 2001 | 10 | 2001 |
| Methods and systems for assessment of turbidity kinetics (waveform analysis) in coagulation testing L Leong, P Ramsey US Patent App. 13/926,966, 2013 | 7 | 2013 |
| Evaluation of methods for potency testing of PEGylated FVIII (PEG-FVIII, BAY 94-9027) L Leong, V Evans, P Ramsey, L Tang, JE Murphy, H Apeler, T Myles, ... JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9, 379-379, 2011 | 7 | 2011 |
| Preservation of activity and prolonged efficacy of rFVIII after site-specific modification with high molecular weight hydroxyethyl starch J Sommer, D Sim, L Leong, F Hacket, B Subramanyam, J Haaning Haemophilia 16, 39-39, 2010 | 3 | 2010 |
| Reduced polyethylene glycol-conjugated b-domain–deleted factor VIII (PEG-BDD-FVIII) clearance: selective PEG steric modulation without affecting potency E Blasko, L Leong, DS Sim, L Tang, E Ho, J Wu, KZ Kauser, ... Blood 124 (21), 1471, 2014 | 1 | 2014 |
| Variant factor VIII polypeptides and methods of their production and use U Gritzan, P Kretschmer, L Leong, C Patel US Patent 10,266,583, 2019 | | 2019 |
| Bay 94-9027 Can be Accurately Measured across Regions with Appropriate One-Stage Assay Reagent Use RK Pruthi, DD Castellone, N Church, L Leong, S Kitchen Blood 132, 2481, 2018 | | 2018 |
| Preliminary Results from a Global Comparative Laboratory Field Study with Bay 94-9027, A Site-Specifically Pegylated Recombinant Factor VIII Product N Church, L Leong, Y Katterle, YR Danda, HF Ulbrich, I Noerenberg, ... PEDIATRIC BLOOD & CANCER 64, S16-S16, 2017 | | 2017 |
Mark H GinsbergUniversity of California San DiegoVerified email at ucsd.edu
