| Oral delivery of peptide drugs: barriers and developments JH Hamman, GM Enslin, AF Kotzé BioDrugs 19, 165-177, 2005 | 625 | 2005 |
| Preparation and NMR characterization of highly substitutedN-trimethyl chitosan chloride AB Sieval, M Thanou, AF Kotze, JC Verhoef, J Brussee, HE Junginger Carbohydrate Polymers 36 (2-3), 157-165, 1998 | 555 | 1998 |
| Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2) AF Kotzé, HL Lueßen, BJ de Leeuw, JC Verhoef, HE Junginger Journal of controlled release 51 (1), 35-46, 1998 | 359 | 1998 |
| Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs SM Van der Merwe, JC Verhoef, JHM Verheijden, AF Kotzé, ... European journal of pharmaceutics and biopharmaceutics 58 (2), 225-235, 2004 | 348 | 2004 |
| Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers MM Thanou, AF Kotze, T Scharringhausen, HL Luessen, AG De Boer, ... Journal of Controlled Release 64 (1-3), 15-25, 2000 | 348 | 2000 |
| Chitosan for enhanced intestinal permeability: prospects for derivatives soluble in neutral and basic environments AF Kotze, HL Luessen, AG De Boer, JC Verhoef, HE Junginger European journal of pharmaceutical sciences 7 (2), 145-151, 1999 | 242 | 1999 |
| Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro HL Lueßen, CO Rentel, AF Kotzé, CM Lehr, AG De Boer, JC Verhoef, ... Journal of controlled release 45 (1), 15-23, 1997 | 230 | 1997 |
| Enhancement of paracellular drug transport with highly quaternized N‐trimethyl chitosan chloride in neutral environments: In vitro evaluation in intestinal epithelial cells … AF Kotzé, MM Thanou, HL Lueben, AG De Boer, JC Verhoef, ... Journal of pharmaceutical sciences 88 (2), 253-257, 1999 | 216 | 1999 |
| Effect of the degree of quaternisation of N-trimethyl chitosan chloride on absorption enhancement: in vivo evaluation in rat nasal epithelia JH Hamman, M Stander, AF Kotze International journal of pharmaceutics 232 (1-2), 235-242, 2002 | 190 | 2002 |
| The relationship between the absolute molecular weight and the degree of quaternisation of N-trimethyl chitosan chloride D Snyman, JH Hamman, JS Kotze, JE Rollings, AF Kotze Carbohydrate polymers 50 (2), 145-150, 2002 | 177 | 2002 |
| Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers AF Kotzé, BJ De Leeuw, HL Lueßen, AG De Boer, JC Verhoef, ... International journal of pharmaceutics 159 (2), 243-253, 1997 | 171 | 1997 |
| Effect of the degree of quaternization of N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2) AF Kotzé, MM Thanou, HL Lueßen, JC Verhoef, HE Junginger European Journal of Pharmaceutics and Biopharmaceutics 47 (3), 269-274, 1999 | 145 | 1999 |
| Evaluation of the mucoadhesive properties of N-trimethyl chitosan chloride D Snyman, JH Hamman, AF Kotze Drug development and industrial pharmacy 29 (1), 61-69, 2003 | 143 | 2003 |
| N-trimethyl chitosan chloride: optimum degree of quaternization for drug absorption enhancement across epithelial cells JH Hamman, CM Schultz, AF Kotzé Drug development and industrial pharmacy 29 (2), 161-172, 2003 | 132 | 2003 |
| Effect of the type of base and number of reaction steps on the degree of quaternization and molecular weight of N-trimethyl chitosan chloride JH Hamman, AF Kotze Drug development and industrial pharmacy 27 (5), 373-380, 2001 | 115 | 2001 |
| Intestinal paracellular permeation enhancement with quaternised chitosan: in situ and in vitro evaluation C Jonker, JH Hamman, AF Kotze International journal of pharmaceutics 238 (1-2), 205-213, 2002 | 111 | 2002 |
| Synthesis and evaluation of the mucoadhesivity of a CD-chitosan derivative JP Venter, AF Kotze, R Auzély-Velty, M Rinaudo International journal of pharmaceutics 313 (1-2), 36-42, 2006 | 106 | 2006 |
| N-trimethyl chitosan chloride as absorption enhancer in oral peptide drug delivery. Development and characterization of minitablet and granule formulations SM Van der Merwe, JC Verhoef, AF Kotze, HE Junginger European journal of pharmaceutics and biopharmaceutics 57 (1), 85-91, 2004 | 80 | 2004 |
| Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets JM Viljoen, JH Steenekamp, AF Marais, AF Kotzé Drug development and industrial pharmacy 40 (6), 730-742, 2014 | 68 | 2014 |
| Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride LH Du Plessis, AF Kotzé, HE Junginger Drug Delivery 17 (6), 399-407, 2010 | 64 | 2010 |
