A.F. Kotze
A.F. Kotze
Pharmacen, North-West Univesrsity, Potchefstroom, 2520, South Africa
Verified email at nwu.ac.za
TitleCited byYear
Oral delivery of peptide drugs
JH Hamman, GM Enslin, AF Kotzé
BioDrugs 19 (3), 165-177, 2005
4592005
Preparation and NMR characterization of highly substitutedN-trimethyl chitosan chloride
AB Sieval, M Thanou, AF Kotze, JC Verhoef, J Brussee, HE Junginger
Carbohydrate Polymers 36 (2-3), 157-165, 1998
4301998
Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
AF Kotzé, HL Lueßen, BJ de Leeuw, JC Verhoef, HE Junginger
Journal of Controlled Release 51 (1), 35-46, 1998
2991998
Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs
SM Van der Merwe, JC Verhoef, JHM Verheijden, AF Kotzé, ...
European journal of pharmaceutics and biopharmaceutics 58 (2), 225-235, 2004
2922004
Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers
MM Thanou, AF Kotze, T Scharringhausen, HL Luessen, AG De Boer, ...
Journal of Controlled Release 64 (1-3), 15-25, 2000
2692000
Chitosan for enhanced intestinal permeability: prospects for derivatives soluble in neutral and basic environments
AF Kotze, HL Luessen, AG De Boer, JC Verhoef, HE Junginger
European journal of pharmaceutical sciences 7 (2), 145-151, 1999
2011999
Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro
HL Lueßen, CO Rentel, AF Kotzé, CM Lehr, AG De Boer, JC Verhoef, ...
Journal of Controlled Release 45 (1), 15-23, 1997
1921997
Bioadhesive drug delivery systems: fundamentals, novel approaches, and development
E Mathiowitz, DE Chickering III, CM Lehr
CRC Press, 1999
1831999
Enhancement of paracellular drug transport with highly quaternized N‐trimethyl chitosan chloride in neutral environments: In vitro evaluation in intestinal epithelial cells …
AF Kotzé, MM Thanou, HL Lueben, AG De Boer, JC Verhoef, ...
Journal of pharmaceutical sciences 88 (2), 253-257, 1999
1741999
Effect of the degree of quaternisation of N-trimethyl chitosan chloride on absorption enhancement: in vivo evaluation in rat nasal epithelia
JH Hamman, M Stander, AF Kotze
International journal of pharmaceutics 232 (1-2), 235-242, 2002
1702002
Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers
AF Kotzé, BJ De Leeuw, HL Lueßen, AG De Boer, JC Verhoef, ...
International journal of pharmaceutics 159 (2), 243-253, 1997
1461997
The relationship between the absolute molecular weight and the degree of quaternisation of N-trimethyl chitosan chloride
D Snyman, JH Hamman, JS Kotze, JE Rollings, AF Kotze
Carbohydrate polymers 50 (2), 145-150, 2002
1412002
Effect of the degree of quaternization of N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
AF Kotzé, MM Thanou, HL Lueßen, JC Verhoef, HE Junginger
European Journal of Pharmaceutics and Biopharmaceutics 47 (3), 269-274, 1999
1221999
Evaluation of the mucoadhesive properties of N-trimethyl chitosan chloride
D Snyman, JH Hamman, AF Kotze
Drug development and industrial pharmacy 29 (1), 61-69, 2003
1172003
N-trimethyl chitosan chloride: optimum degree of quaternization for drug absorption enhancement across epithelial cells
JH Hamman, CM Schultz, AF Kotzé
Drug development and industrial pharmacy 29 (2), 161-172, 2003
1062003
Intestinal paracellular permeation enhancement with quaternised chitosan: in situ and in vitro evaluation
C Jonker, JH Hamman, AF Kotze
International journal of pharmaceutics 238 (1-2), 205-213, 2002
912002
Effect of the type of base and number of reaction steps on the degree of quaternization and molecular weight of N-trimethyl chitosan chloride
JH Hamman, AF Kotze
Drug development and industrial pharmacy 27 (5), 373-380, 2001
852001
N-trimethyl chitosan chloride as absorption enhancer in oral peptide drug delivery. Development and characterization of minitablet and granule formulations
SM Van der Merwe, JC Verhoef, AF Kotze, HE Junginger
European journal of pharmaceutics and biopharmaceutics 57 (1), 85-91, 2004
642004
Synthesis and evaluation of the mucoadhesivity of a CD-chitosan derivative
JP Venter, AF Kotze, R Auzely-Velty, M Rinaudo
International journal of pharmaceutics 313 (1-2), 36-42, 2006
622006
Chitosan and chitosan derivatives as absorption enhancers for peptide drugs across mucosal epithelia
AF Kotzé, HL Luessen, M Thanou, J Coos Verhoef, AG De Boer, ...
Drugs and the pharmaceutical sciences 98, 341-386, 1999
491999
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