Gilla Kaplan
Gilla Kaplan
Hon. Prof. University of Cape Town
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Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.
EP Sampaio, EN Sarno, R Galilly, ZA Cohn, G Kaplan
The Journal of experimental medicine 173 (3), 699-703, 1991
Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation.
AL Moreira, EP Sampaio, A Zmuidzinas, P Frindt, KA Smith, G Kaplan
The Journal of experimental medicine 177 (6), 1675-1680, 1993
Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-α
LG Corral, PAJ Haslett, GW Muller, R Chen, LM Wong, CJ Ocampo, ...
The Journal of Immunology 163 (1), 380-386, 1999
A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
MB Reed, P Domenech, C Manca, H Su, AK Barczak, BN Kreiswirth, ...
Nature 431 (7004), 84-87, 2004
Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β
C Manca, L Tsenova, A Bergtold, S Freeman, M Tovey, JM Musser, ...
Proceedings of the National Academy of Sciences 98 (10), 5752-5757, 2001
Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset
PAJ Haslett, LG Corral, M Albert, G Kaplan
The Journal of experimental medicine 187 (11), 1885-1892, 1998
Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.
A Molloy, P Laochumroonvorapong, G Kaplan
The Journal of experimental medicine 180 (4), 1499-1509, 1994
Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
KC El Kasmi, JE Qualls, JT Pesce, AM Smith, RW Thompson, ...
Nature immunology 9 (12), 1399-1406, 2008
Human dendritic cells. Enrichment and characterization from peripheral blood
WC Van Voorhis, LS Hair, RM Steinman, G Kaplan
The Journal of experimental medicine 155 (4), 1172-1187, 1982
The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum
EP Sampaio, G Kaplan, A Miranda, JAC Nery, CP Miguel, SM Viana, ...
Journal of Infectious Diseases 168 (2), 408-414, 1993
Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns
BMN Kagina, B Abel, TJ Scriba, EJ Hughes, A Keyser, A Soares, ...
American journal of respiratory and critical care medicine 182 (8), 1073-1079, 2010
Amino-substituted thalidomide analogs: potent inhibitors of TNF-α production
GW Muller, R Chen, SY Huang, LG Corral, LM Wong, RT Patterson, ...
Bioorganic & medicinal chemistry letters 9 (11), 1625-1630, 1999
Metformin as adjunct antituberculosis therapy
A Singhal, L Jie, P Kumar, GS Hong, MKS Leow, B Paleja, L Tsenova, ...
Science translational medicine 6 (263), 263ra159-263ra159, 2014
Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism
MJ Kim, HC Wainwright, M Locketz, LG Bekker, GB Walther, C Dittrich, ...
EMBO molecular medicine 2 (7), 258-274, 2010
Mycobacterium tuberculosis Growth at theCavity Surface: a Microenvironment with FailedImmunity
G Kaplan, FA Post, AL Moreira, H Wainwright, BN Kreiswirth, M Tanverdi, ...
Infection and immunity 71 (12), 7099-7108, 2003
The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice
JL Dahl, CN Kraus, HIM Boshoff, B Doan, K Foley, D Avarbock, G Kaplan, ...
Proceedings of the National Academy of Sciences 100 (17), 10026-10031, 2003
Local and systemic effects of intradermal recombinant interferon-γ in patients with lepromatous leprosy
CF Nathan, G Kaplan, WR Levis, A Nusrat, MD Witmer, SA Sherwin, ...
New England Journal of Medicine 315 (1), 6-15, 1986
Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates
C Manca, L Tsenova, CE Barry, A Bergtold, S Freeman, PAJ Haslett, ...
The Journal of Immunology 162 (11), 6740-6746, 1999
Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load
CL Day, DA Abrahams, L Lerumo, EJ van Rensburg, L Stone, T O’rie, ...
The Journal of Immunology 187 (5), 2222-2232, 2011
The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin.
G Kaplan, AD Luster, G Hancock, ZA Cohn
The Journal of experimental medicine 166 (4), 1098-1108, 1987
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