Robert G. Thorne
Robert G. Thorne
Denali Fellow, Denali Therapeutics
Verified email at - Homepage
Cited by
Cited by
Intranasal delivery of biologics to the central nervous system
JJ Lochhead, RG Thorne
Advanced drug delivery reviews 64 (7), 614-628, 2012
Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
RG Thorne, GJ Pronk, V Padmanabhan, WH Frey Ii
Neuroscience 127 (2), 481-496, 2004
In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space
RG Thorne, C Nicholson
Proceedings of the National Academy of Sciences 103 (14), 5567-5572, 2006
Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations
RG Thorne, WH Frey
Clinical pharmacokinetics 40, 907-946, 2001
The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’system?
NJ Abbott, ME Pizzo, JE Preston, D Janigro, RG Thorne
Acta neuropathologica 135, 387-407, 2018
Quantitative analysis of the olfactory pathway for drug delivery to the brain
RG Thorne, CR Emory, TA Ala, WH Frey II
Brain research 692 (1-2), 278-282, 1995
Diffusion of macromolecules in the brain: implications for drug delivery
DJ Wolak, RG Thorne
Molecular pharmaceutics 10 (5), 1492-1504, 2013
Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage
XF Liu, JR Fawcett, RG Thorne, TA DeFor, WH Frey II
Journal of the neurological sciences 187 (1-2), 91-97, 2001
Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy …
TM Ross, PM Martinez, JC Renner, RG Thorne, LR Hanson, WH Frey Ii
Journal of neuroimmunology 151 (1-2), 66-77, 2004
Delivery of 125I-NGF to the brain via the olfactory route
WH Frey, J Liu, X Chen, RG Thorne, JR Fawcett, TA Ala, YE Rahman
Drug Delivery 4 (2), 87-92, 1997
Delivery of interferon-β to the monkey nervous system following intranasal administration
RG Thorne, LR Hanson, TM Ross, D Tung, WH Frey Ii
Neuroscience 152 (3), 785-797, 2008
Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration
JJ Lochhead, DJ Wolak, ME Pizzo, RG Thorne
Journal of Cerebral Blood Flow & Metabolism 35 (3), 371-381, 2015
Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery
ME Pizzo, DJ Wolak, NN Kumar, E Brunette, CL Brunnquell, MJ Hannocks, ...
The Journal of physiology 596 (3), 445-475, 2018
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
MS Kariolis, RC Wells, JA Getz, W Kwan, CS Mahon, R Tong, DJ Kim, ...
Science translational medicine 12 (545), eaay1359, 2020
Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging
RG Thorne, S Hrabetová, C Nicholson
Journal of neurophysiology 92 (6), 3471-3481, 2004
Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion
XF Liu, JR Fawcett, RG Thorne, WH Frey Ii
Neuroscience letters 308 (2), 91-94, 2001
In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate
RG Thorne, A Lakkaraju, E Rodriguez-Boulan, C Nicholson
Proceedings of the National Academy of Sciences 105 (24), 8416-8421, 2008
Molecular characterization of perivascular drainage pathways in the murine brain
MJ Hannocks, ME Pizzo, J Huppert, T Deshpande, NJ Abbott, RG Thorne, ...
Journal of Cerebral Blood Flow & Metabolism 38 (4), 669-686, 2018
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
JC Ullman, A Arguello, JA Getz, A Bhalla, CS Mahon, J Wang, T Giese, ...
Science Translational Medicine 12 (545), eaay1163, 2020
Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery
NN Kumar, JJ Lochhead, ME Pizzo, G Nehra, S Boroumand, G Greene, ...
Journal of controlled release 286, 467-484, 2018
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