| Intranasal delivery of biologics to the central nervous system JJ Lochhead, RG Thorne Advanced drug delivery reviews 64 (7), 614-628, 2012 | 1162 | 2012 |
| Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration RG Thorne, GJ Pronk, V Padmanabhan, WH Frey Ii Neuroscience 127 (2), 481-496, 2004 | 1109 | 2004 |
| In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space RG Thorne, C Nicholson Proceedings of the National Academy of Sciences 103 (14), 5567-5572, 2006 | 718 | 2006 |
| Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations RG Thorne, WH Frey Clinical pharmacokinetics 40, 907-946, 2001 | 591 | 2001 |
| The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’system? NJ Abbott, ME Pizzo, JE Preston, D Janigro, RG Thorne Acta neuropathologica 135, 387-407, 2018 | 579 | 2018 |
| Quantitative analysis of the olfactory pathway for drug delivery to the brain RG Thorne, CR Emory, TA Ala, WH Frey II Brain research 692 (1-2), 278-282, 1995 | 458 | 1995 |
| Diffusion of macromolecules in the brain: implications for drug delivery DJ Wolak, RG Thorne Molecular pharmaceutics 10 (5), 1492-1504, 2013 | 319 | 2013 |
| Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage XF Liu, JR Fawcett, RG Thorne, TA DeFor, WH Frey II Journal of the neurological sciences 187 (1-2), 91-97, 2001 | 315 | 2001 |
| Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy … TM Ross, PM Martinez, JC Renner, RG Thorne, LR Hanson, WH Frey Ii Journal of neuroimmunology 151 (1-2), 66-77, 2004 | 302 | 2004 |
| Delivery of 125I-NGF to the brain via the olfactory route WH Frey, J Liu, X Chen, RG Thorne, JR Fawcett, TA Ala, YE Rahman Drug Delivery 4 (2), 87-92, 1997 | 289 | 1997 |
| Delivery of interferon-β to the monkey nervous system following intranasal administration RG Thorne, LR Hanson, TM Ross, D Tung, WH Frey Ii Neuroscience 152 (3), 785-797, 2008 | 286 | 2008 |
| Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration JJ Lochhead, DJ Wolak, ME Pizzo, RG Thorne Journal of Cerebral Blood Flow & Metabolism 35 (3), 371-381, 2015 | 265 | 2015 |
| Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery ME Pizzo, DJ Wolak, NN Kumar, E Brunette, CL Brunnquell, MJ Hannocks, ... The Journal of physiology 596 (3), 445-475, 2018 | 241 | 2018 |
| Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys MS Kariolis, RC Wells, JA Getz, W Kwan, CS Mahon, R Tong, DJ Kim, ... Science translational medicine 12 (545), eaay1359, 2020 | 227 | 2020 |
| Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging RG Thorne, S Hrabetová, C Nicholson Journal of neurophysiology 92 (6), 3471-3481, 2004 | 213 | 2004 |
| Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion XF Liu, JR Fawcett, RG Thorne, WH Frey Ii Neuroscience letters 308 (2), 91-94, 2001 | 196 | 2001 |
| In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate RG Thorne, A Lakkaraju, E Rodriguez-Boulan, C Nicholson Proceedings of the National Academy of Sciences 105 (24), 8416-8421, 2008 | 160 | 2008 |
| Molecular characterization of perivascular drainage pathways in the murine brain MJ Hannocks, ME Pizzo, J Huppert, T Deshpande, NJ Abbott, RG Thorne, ... Journal of Cerebral Blood Flow & Metabolism 38 (4), 669-686, 2018 | 156 | 2018 |
| Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice JC Ullman, A Arguello, JA Getz, A Bhalla, CS Mahon, J Wang, T Giese, ... Science Translational Medicine 12 (545), eaay1163, 2020 | 153 | 2020 |
| A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models B van Lengerich, L Zhan, D Xia, D Chan, D Joy, JI Park, D Tatarakis, ... Nature neuroscience 26 (3), 416-429, 2023 | 88 | 2023 |
