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Robert G. Thorne
Robert G. Thorne
Denali Fellow, Denali Therapeutics
Verified email at dnli.com - Homepage
Title
Cited by
Cited by
Year
Intranasal delivery of biologics to the central nervous system
JJ Lochhead, RG Thorne
Advanced drug delivery reviews 64 (7), 614-628, 2012
11482012
Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
RG Thorne, GJ Pronk, V Padmanabhan, WH Frey Ii
Neuroscience 127 (2), 481-496, 2004
10962004
In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space
RG Thorne, C Nicholson
Proceedings of the National Academy of Sciences 103 (14), 5567-5572, 2006
7052006
Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations
RG Thorne, WH Frey
Clinical pharmacokinetics 40, 907-946, 2001
5892001
The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’system?
NJ Abbott, ME Pizzo, JE Preston, D Janigro, RG Thorne
Acta neuropathologica 135, 387-407, 2018
5712018
Quantitative analysis of the olfactory pathway for drug delivery to the brain
RG Thorne, CR Emory, TA Ala, WH Frey II
Brain research 692 (1-2), 278-282, 1995
4521995
Diffusion of macromolecules in the brain: implications for drug delivery
DJ Wolak, RG Thorne
Molecular pharmaceutics 10 (5), 1492-1504, 2013
3142013
Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage
XF Liu, JR Fawcett, RG Thorne, TA DeFor, WH Frey II
Journal of the neurological sciences 187 (1-2), 91-97, 2001
3112001
Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy …
TM Ross, PM Martinez, JC Renner, RG Thorne, LR Hanson, WH Frey Ii
Journal of neuroimmunology 151 (1-2), 66-77, 2004
2952004
Delivery of 125I-NGF to the brain via the olfactory route
WH Frey, J Liu, X Chen, RG Thorne, JR Fawcett, TA Ala, YE Rahman
Drug Delivery 4 (2), 87-92, 1997
2881997
Delivery of interferon-β to the monkey nervous system following intranasal administration
RG Thorne, LR Hanson, TM Ross, D Tung, WH Frey Ii
Neuroscience 152 (3), 785-797, 2008
2802008
Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration
JJ Lochhead, DJ Wolak, ME Pizzo, RG Thorne
Journal of Cerebral Blood Flow & Metabolism 35 (3), 371-381, 2015
2612015
Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery
ME Pizzo, DJ Wolak, NN Kumar, E Brunette, CL Brunnquell, MJ Hannocks, ...
The Journal of physiology 596 (3), 445-475, 2018
2382018
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
MS Kariolis, RC Wells, JA Getz, W Kwan, CS Mahon, R Tong, DJ Kim, ...
Science translational medicine 12 (545), eaay1359, 2020
2232020
Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging
RG Thorne, S Hrabetová, C Nicholson
Journal of neurophysiology 92 (6), 3471-3481, 2004
2132004
Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion
XF Liu, JR Fawcett, RG Thorne, WH Frey Ii
Neuroscience letters 308 (2), 91-94, 2001
1962001
In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate
RG Thorne, A Lakkaraju, E Rodriguez-Boulan, C Nicholson
Proceedings of the National Academy of Sciences 105 (24), 8416-8421, 2008
1582008
Molecular characterization of perivascular drainage pathways in the murine brain
MJ Hannocks, ME Pizzo, J Huppert, T Deshpande, NJ Abbott, RG Thorne, ...
Journal of Cerebral Blood Flow & Metabolism 38 (4), 669-686, 2018
1542018
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
JC Ullman, A Arguello, JA Getz, A Bhalla, CS Mahon, J Wang, T Giese, ...
Science Translational Medicine 12 (545), eaay1163, 2020
1472020
Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery
NN Kumar, JJ Lochhead, ME Pizzo, G Nehra, S Boroumand, G Greene, ...
Journal of controlled release 286, 467-484, 2018
872018
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