Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation SJ Jenkins, D Ruckerl, PC Cook, LH Jones, FD Finkelman, N van Rooijen, ... Science 332 (6035), 1284-1288, 2011 | 1640 | 2011 |
CD11c depletion severely disrupts Th2 induction and development in vivo AT Phythian-Adams, PC Cook, RJ Lundie, LH Jones, KA Smith, TA Barr, ... Journal of Experimental Medicine 207 (10), 2089-2096, 2010 | 318 | 2010 |
The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation FR Svedberg, SL Brown, MZ Krauss, L Campbell, C Sharpe, M Clausen, ... Nature immunology 20 (5), 571-580, 2019 | 177 | 2019 |
Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo PC Cook, LH Jones, SJ Jenkins, TA Wynn, JE Allen, AS MacDonald Proceedings of the National Academy of Sciences 109 (25), 9977-9982, 2012 | 153 | 2012 |
Dynamics of colon monocyte and macrophage activation during colitis GR Jones, CC Bain, T Fenton, A Kelly, S Brown, A Ivens, M Travis, ... Frontiers in immunology 9, 2764, 2018 | 147 | 2018 |
The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung T Fujimori, AM Grabiec, M Kaur, TJ Bell, N Fujino, PC Cook, FR Svedberg, ... Mucosal immunology 8 (5), 1021-1030, 2015 | 126 | 2015 |
CD4+ CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection JD Turner, GR Jenkins, KG Hogg, SA Aynsley, RA Paveley, PC Cook, ... PLoS Negl Trop Dis 5 (8), e1269, 2011 | 108 | 2011 |
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus T Furukawa, N van Rhijn, M Fraczek, F Gsaller, E Davies, P Carr, S Gago, ... Nature Communications 11 (1), 1-16, 2020 | 106 | 2020 |
The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ … RA Paveley, SA Aynsley, JD Turner, CD Bourke, SJ Jenkins, PC Cook, ... International journal for parasitology 41 (13-14), 1335-1345, 2011 | 105 | 2011 |
Dendritic cells in lung immunopathology PC Cook, AS MacDonald Seminars in immunopathology 38 (4), 449-460, 2016 | 96 | 2016 |
Pathogenesis of Respiratory Viral and Fungal Coinfections F Salazar, E Bignell, GD Brown, PC Cook, A Warris Clinical Microbiology Reviews 35 (1), e00094-21, 2021 | 92 | 2021 |
Type I interferon is required for T helper (Th) 2 induction by dendritic cells LM Webb, RJ Lundie, JG Borger, SL Brown, LM Connor, ANR Cartwright, ... The EMBO journal 36 (16), 2404-2418, 2017 | 86 | 2017 |
A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells PC Cook, H Owen, AM Deaton, JG Borger, SL Brown, T Clouaire, ... Nature communications 6 (1), 1-11, 2015 | 85 | 2015 |
Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells RA Paveley, SA Aynsley, PC Cook, JD Turner, AP Mountford PLoS neglected tropical diseases 3 (10), e528, 2009 | 79 | 2009 |
Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype VL Morrison, MJ James, K Grzes, P Cook, DG Glass, T Savinko, ... Nature communications 5, 5359, 2014 | 68 | 2014 |
Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma AM Grabiec, N Denny, JA Doherty, KE Happonen, J Hankinson, ... Journal of Allergy and Clinical Immunology 140 (4), 1144-1146. e4, 2017 | 56 | 2017 |
Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells PC Cook, SA Aynsley, JD Turner, GR Jenkins, N Van Rooijen, M Leeto, ... PLoS pathogens 7 (3), e1001323, 2011 | 56 | 2011 |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function AJ Bancroft, CW Levy, TA Jowitt, KS Hayes, S Thompson, EA Mckenzie, ... Nature communications 10 (1), 2344, 2019 | 55 | 2019 |
Integrin α4β1 controls G9a activity that regulates epigenetic changes and nuclear properties required for lymphocyte migration X Zhang, PC Cook, E Zindy, CJ Williams, TA Jowitt, CH Streuli, ... Nucleic acids research 44 (7), 3031-3044, 2016 | 42 | 2016 |
Schistosomes in the lung: immunobiology and opportunity EL Houlder, AH Costain, PC Cook, AS MacDonald Frontiers in Immunology 12, 1330, 2021 | 40 | 2021 |