| Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens A Dixit, O Parnas, B Li, J Chen, CP Fulco, L Jerby-Arnon, ND Marjanovic, ... cell 167 (7), 1853-1866. e17, 2016 | 1629 | 2016 |
| A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade L Jerby-Arnon, P Shah, MS Cuoco, C Rodman, MJ Su, JC Melms, ... Cell 175 (4), 984-997. e24, 2018 | 1197 | 2018 |
| Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma D Liu, B Schilling, D Liu, A Sucker, E Livingstone, L Jerby-Arnon, ... Nature medicine 25 (12), 1916-1927, 2019 | 806 | 2019 |
| Predicting selective drug targets in cancer through metabolic networks O Folger, L Jerby, C Frezza, E Gottlieb, E Ruppin, T Shlomi Molecular systems biology 7 (1), 501, 2011 | 613 | 2011 |
| A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors M Slyper, CBM Porter, O Ashenberg, J Waldman, E Drokhlyansky, ... Nature medicine 26 (5), 792-802, 2020 | 575 | 2020 |
| Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase C Frezza, L Zheng, O Folger, KN Rajagopalan, ED MacKenzie, L Jerby, ... Nature 477 (7363), 225-228, 2011 | 566 | 2011 |
| Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism J Livnat, S Tomer, E Ruppin Molecular systems biology 6 (1), 2010 | 463 | 2010 |
| A single-cell landscape of high-grade serous ovarian cancer B Izar, I Tirosh, EH Stover, I Wakiro, MS Cuoco, I Alter, C Rodman, ... Nature medicine 26 (8), 1271-1279, 2020 | 389 | 2020 |
| Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis ND Mathewson, O Ashenberg, I Tirosh, S Gritsch, EM Perez, S Marx, ... Cell 184 (5), 1281-1298. e26, 2021 | 324 | 2021 |
| Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality L Jerby-Arnon, N Pfetzer, YY Waldman, L McGarry, D James, E Shanks, ... Cell 158 (5), 1199-1209, 2014 | 314 | 2014 |
| Fumarate induces redox-dependent senescence by modifying glutathione metabolism L Zheng, S Cardaci, L Jerby, ED MacKenzie, M Sciacovelli, TI Johnson, ... Nature communications 6 (1), 6001, 2015 | 306 | 2015 |
| Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion CJ Frangieh, JC Melms, PI Thakore, KR Geiger-Schuller, P Ho, ... Nature genetics 53 (3), 332-341, 2021 | 200 | 2021 |
| Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer L Jerby, L Wolf, C Denkert, GY Stein, M Hilvo, M Oresic, T Geiger, ... Cancer research 72 (22), 5712-5720, 2012 | 163 | 2012 |
| Harnessing synthetic lethality to predict the response to cancer treatment JS Lee, A Das, L Jerby-Arnon, R Arafeh, N Auslander, M Davidson, ... Nature communications 9 (1), 2546, 2018 | 140 | 2018 |
| Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis RA Kamber, Y Nishiga, B Morton, AM Banuelos, AA Barkal, ... Nature 597 (7877), 549-554, 2021 | 138 | 2021 |
| Predicting drug targets and biomarkers of cancer via genome-scale metabolic modeling L Jerby, E Ruppin Clinical Cancer Research 18 (20), 5572-5584, 2012 | 129 | 2012 |
| Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease T Hyötyläinen, L Jerby, EM Petäjä, I Mattila, S Jäntti, P Auvinen, ... Nature communications 7 (1), 8994, 2016 | 123 | 2016 |
| Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma L Jerby-Arnon, C Neftel, ME Shore, HR Weisman, ND Mathewson, ... Nature medicine 27 (2), 289-300, 2021 | 105 | 2021 |
| Massively parallel phenotyping of coding variants in cancer with Perturb-seq O Ursu, JT Neal, E Shea, PI Thakore, L Jerby-Arnon, L Nguyen, D Dionne, ... Nature biotechnology 40 (6), 896-905, 2022 | 87 | 2022 |
| A distinct transcriptional program in human CAR T cells bearing the 4-1BB signaling domain revealed by scRNA-seq AC Boroughs, RC Larson, ND Marjanovic, K Gosik, AP Castano, ... Molecular Therapy 28 (12), 2577-2592, 2020 | 83 | 2020 |
Eytan RuppinChief, Cancer Data Science Lab (CDSL), NCI/NIHVerified email at nih.gov
