| Artemisone and artemiside are potent panreactive antimalarial agents that also synergize redox imbalance in Plasmodium falciparum transmissible gametocyte stages D Coertzen, J Reader, M Van Der Watt, SH Nondaba, L Gibhard, ... Antimicrobial Agents and Chemotherapy 62 (8), 10.1128/aac. 02214-17, 2018 | 43 | 2018 |
| Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives C De Lange, D Coertzen, FJ Smit, JF Wentzel, HN Wong, LM Birkholtz, ... Bioorganic & medicinal chemistry letters 28 (3), 289-292, 2018 | 41 | 2018 |
| Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1, 2-disubstituted ferrocene hybrids C De Lange, D Coertzen, FJ Smit, JF Wentzel, HN Wong, LM Birkholtz, ... Bioorganic & Medicinal Chemistry Letters 28 (19), 3161-3163, 2018 | 33 | 2018 |
| Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites RM Beteck, R Seldon, D Coertzen, ME van der Watt, J Reader, ... Communications Chemistry 1 (1), 62, 2018 | 33 | 2018 |
| Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites M Leshabane, GA Dziwornu, D Coertzen, J Reader, P Moyo, ... ACS Infectious Diseases 7 (7), 1945-1955, 2021 | 23 | 2021 |
| Antimalarial benzimidazole derivatives incorporating phenolic mannich base side chains inhibit microtubule and hemozoin formation: structure–activity relationship and in vivo … GA Dziwornu, D Coertzen, M Leshabane, CM Korkor, CK Cloete, ... Journal of medicinal chemistry 64 (8), 5198-5215, 2021 | 20 | 2021 |
| Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities RM Beteck, D Coertzen, FJ Smit, LM Birkholtz, RK Haynes, DD N’Da Bioorganic & Medicinal Chemistry Letters 26 (13), 3006-3009, 2016 | 20 | 2016 |
| Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum S-adenosylmethionine decarboxylase protein produced in Escherichia coli XH Makhoba, A Burger, D Coertzen, T Zininga, LM Birkholtz, A Shonhai PLoS One 11 (3), e0152626, 2016 | 20 | 2016 |
| Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies–activities against blood stage P. falciparum Including Pf … HN Wong, V Padin-Irizarry, ME van der Watt, J Reader, W Liebenberg, ... Frontiers in Chemistry 7, 901, 2020 | 17 | 2020 |
| Preliminary evaluation of artemisinin–cholesterol conjugates as potential drugs for the treatment of intractable forms of malaria and tuberculosis M Morake, D Coertzen, A Ngwane, JF Wentzel, HN Wong, FJ Smit, ... ChemMedChem 13 (1), 67-77, 2018 | 16 | 2018 |
| Activities of 11‐Azaartemisinin and N‐Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites R Harmse, D Coertzen, HN Wong, FJ Smit, ME van der Watt, J Reader, ... ChemMedChem 12 (24), 2086-2093, 2017 | 16 | 2017 |
| Antimalarial N1,N3-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure–activity Relationships S Ahenkorah, D Coertzen, JX Tong, K Fridianto, S Wittlin, LM Birkholtz, ... ACS medicinal chemistry letters 11 (1), 49-55, 2019 | 15 | 2019 |
| New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and … PM Cheuka, L Centani, LB Arendse, S Fienberg, L Wambua, SS Renga, ... ACS Infectious Diseases 7 (1), 34-46, 2020 | 12 | 2020 |
| The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages LB Arendse, JM Murithi, T Qahash, CFA Pasaje, LC Godoy, S Dey, ... Science translational medicine 14 (667), eabo7219, 2022 | 11 | 2022 |
| Facile route to targeted, biodegradable polymeric prodrugs for the delivery of combination therapy for malaria L Fortuin, M Leshabane, R Pfukwa, D Coertzen, LM Birkholtz, ... ACS Biomaterials Science & Engineering 6 (11), 6217-6227, 2020 | 11 | 2020 |
| Structure–Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro D Mambwe, M Kumar, R Ferger, D Taylor, M Njoroge, D Coertzen, ... ACS Medicinal Chemistry Letters 12 (8), 1333-1341, 2021 | 8 | 2021 |
| Poly(N-vinylpyrrolidone) Antimalaria Conjugates of Membrane-Disruptive Peptides S Jokonya, M Langlais, M Leshabane, PW Reader, JA Vosloo, R Pfukwa, ... Biomacromolecules 21 (12), 5053-5066, 2020 | 7 | 2020 |
| Synthesis and testing of analogs of the tuberculosis drug candidate SQ109 against bacteria and protozoa: identification of lead compounds against Mycobacterium abscessus and … M Stampolaki, SR Malwal, N Alvarez-Cabrera, Z Gao, M Moniruzzaman, ... ACS infectious diseases 9 (2), 342-364, 2023 | 6 | 2023 |
| The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside L Gibhard, D Coertzen, J Reader, ME van der Watt, LM Birkholtz, ... Pharmaceutics 13 (12), 2066, 2021 | 5 | 2021 |
| Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse … D Mambwe, CM Korkor, A Mabhula, Z Ngqumba, C Cloete, M Kumar, ... Journal of medicinal chemistry 65 (24), 16695-16715, 2022 | 3 | 2022 |
