Animal models for COVID-19 C Muñoz-Fontela, WE Dowling, SGP Funnell, PS Gsell, AX Riveros-Balta, ... Nature 586 (7830), 509-515, 2020 | 801 | 2020 |
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2− infected hamsters, whereas hydroxychloroquine lacks activity SJF Kaptein, S Jacobs, L Langendries, L Seldeslachts, S Ter Horst, ... Proceedings of the National Academy of Sciences 117 (43), 26955-26965, 2020 | 283 | 2020 |
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters R Boudewijns, HJ Thibaut, SJF Kaptein, R Li, V Vergote, L Seldeslachts, ... Nature communications 11 (1), 5838, 2020 | 276 | 2020 |
Favipiravir (T-705) inhibits in vitro norovirus replication J Rocha-Pereira, D Jochmans, K Dallmeier, P Leyssen, MSJ Nascimento, ... Biochemical and biophysical research communications 424 (4), 777-780, 2012 | 148 | 2012 |
A robust human norovirus replication model in zebrafish larvae J Van Dycke, A Ny, N Conceição-Neto, J Maes, M Hosmillo, A Cuvry, ... PLoS Pathogens 15 (9), e1008009, 2019 | 146 | 2019 |
The Viral Polymerase Inhibitor 2′-C-Methylcytidine Inhibits Norwalk Virus Replication and Protects against Norovirus-Induced Diarrhea and Mortality in a Mouse … J Rocha-Pereira, D Jochmans, Y Debing, E Verbeken, MSJ Nascimento, ... Journal of virology 87 (21), 11798-11805, 2013 | 111 | 2013 |
Inhibition of norovirus replication by the nucleoside analogue 2′-C-methylcytidine J Rocha-Pereira, D Jochmans, K Dallmeier, P Leyssen, R Cunha, I Costa, ... Biochemical and biophysical research communications 427 (4), 796-800, 2012 | 76 | 2012 |
Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model AO Kolawole, J Rocha-Pereira, MD Elftman, J Neyts, CE Wobus Antiviral research 132, 46-49, 2016 | 69 | 2016 |
(E)-2-Styrylchromones as potential anti-norovirus agents J Rocha-Pereira, R Cunha, DCGA Pinto, AMS Silva, MSJ Nascimento Bioorganic & medicinal chemistry 18 (12), 4195-4201, 2010 | 64 | 2010 |
Norovirus: targets and tools in antiviral drug discovery J Rocha-Pereira, J Neyts, D Jochmans Biochemical pharmacology 91 (1), 1-11, 2014 | 58 | 2014 |
The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon J Rocha-Pereira, MSJ Nascimento, Q Ma, R Hilgenfeld, J Neyts, ... Antimicrobial agents and chemotherapy 58 (8), 4675-4681, 2014 | 57 | 2014 |
Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients SGP Funnell, WE Dowling, C Muñoz-Fontela, PS Gsell, DE Ingber, ... Nature Communications 11 (1), 4253, 2020 | 56 | 2020 |
Molecular chaperone Hsp90 is a therapeutic target for noroviruses S Vashist, L Urena, MB Gonzalez-Hernandez, J Choi, A de Rougemont, ... Journal of virology 89 (12), 6352-6363, 2015 | 50 | 2015 |
An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models B Schepens, L van Schie, W Nerinckx, K Roose, W Van Breedam, ... Science Translational Medicine 13 (621), eabi7826, 2021 | 42 | 2021 |
Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones D Kumarasamy, BG Roy, J Rocha-Pereira, J Neyts, S Nanjappan, S Maity, ... Bioorganic & medicinal chemistry letters 27 (2), 139-142, 2017 | 42 | 2017 |
Prophylactic treatment with the nucleoside analogue 2′-C-methylcytidine completely prevents transmission of norovirus J Rocha-Pereira, D Jochmans, J Neyts Journal of Antimicrobial Chemotherapy 70 (1), 190-197, 2015 | 40 | 2015 |
Interferon lambda (IFN-λ) efficiently blocks norovirus transmission in a mouse model J Rocha-Pereira, S Jacobs, S Noppen, E Verbeken, T Michiels, J Neyts Antiviral research 149, 7-15, 2018 | 34 | 2018 |
A single nucleoside viral polymerase inhibitor against norovirus, rotavirus, and sapovirus-induced diarrhea J Van Dycke, F Arnoldi, G Papa, J Vandepoele, OR Burrone, ... The Journal of Infectious Diseases 218 (11), 1753-1758, 2018 | 32 | 2018 |
Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales Y Fernández-García, S Ter Horst, M Bassetto, A Brancale, J Neyts, ... Antiviral Research 183, 104947, 2020 | 31 | 2020 |
Antiviral treatment of SARS-CoV-2-infected hamsters reveals a weak effect of favipiravir and a complete lack of effect for hydroxychloroquine SJF Kaptein, S Jacobs, L Langendries, L Seldeslachts, S ter Horst, ... BioRxiv, 2020.06. 19.159053, 2020 | 31 | 2020 |