Dale Taylor
Dale Taylor
Senior Investigator, H3D Drug Discovery Center, University of Cape Town
Verified email at uct.ac.za - Homepage
Title
Cited by
Cited by
Year
Fate of haem iron in the malaria parasite Plasmodium falciparum.
TJ Egan, JM Combrinck, J Egan, GR Hearne, HM Marques, S Ntenteni, ...
Biochemical Journal 365 (Pt 2), 343, 2002
3502002
Insights into the role of heme in the mechanism of action of antimalarials
JM Combrinck, TE Mabotha, KK Ncokazi, MA Ambele, D Taylor, PJ Smith, ...
ACS chemical biology 8 (1), 133-137, 2013
2042013
Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts
CC Musonda, D Taylor, J Lehman, J Gut, PJ Rosenthal, K Chibale
Bioorganic & medicinal chemistry letters 14 (15), 3901-3905, 2004
852004
Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration
R van der Westhuyzen, S Winks, CR Wilson, GA Boyle, RK Gessner, ...
Journal of medicinal chemistry 58 (23), 9371-9381, 2015
632015
In vitro antimalarial activity, β-haematin inhibition and structure–activity relationships in a series of quinoline triazoles
MC Joshi, KJ Wicht, D Taylor, R Hunter, PJ Smith, TJ Egan
European journal of medicinal chemistry 69, 338-347, 2013
512013
Synthesis and evaluation of new polynuclear organometallic Ru (II), Rh (III) and Ir (III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents
P Chellan, KM Land, A Shokar, A Au, SH An, D Taylor, PJ Smith, T Riedel, ...
Dalton Transactions 43 (2), 513-526, 2014
502014
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy
MN Aminake, A Mahajan, V Kumar, R Hans, L Wiesner, D Taylor, ...
Bioorganic & medicinal chemistry 20 (17), 5277-5289, 2012
492012
Mathematics and science teacher education in South Africa: A review of research, policy and practice in times of change
J Adler, C Pournara, D Taylor, B Thorne, G Moletsane
African Journal of Research in Mathematics, Science and Technology Educationá…, 2009
462009
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle
C Le Manach, AT Nchinda, T Paquet, D GonzÓlez Cabrera, Y Younis, ...
Journal of medicinal chemistry 59 (21), 9890-9905, 2016
402016
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1
C Le Manach, D Gonzàlez Cabrera, F Douelle, AT Nchinda, Y Younis, ...
Journal of medicinal chemistry 57 (6), 2789-2798, 2014
392014
Heterometallic half-sandwich complexes containing a ferrocenyl motif: Synthesis, molecular structure, electrochemistry and antiplasmodial evaluation
W Nkoana, D Nyoni, P Chellan, T Stringer, D Taylor, PJ Smith, AT Hutton, ...
Journal of Organometallic Chemistry 752, 67-75, 2014
332014
2, 4-Diaminothienopyrimidines as orally active antimalarial agents
D González Cabrera, C Le Manach, F Douelle, Y Younis, TS Feng, ...
Journal of medicinal chemistry 57 (3), 1014-1022, 2014
312014
Role of the Neurotransmitter Reuptake-Blocking Activity of Antidepressants in Reversing Chloroquine Resistance In Vitro in Plasmodium falciparum
D Taylor, JC Walden, AH Robins, PJ Smith
Antimicrobial agents and chemotherapy 44 (10), 2689-2692, 2000
312000
UCT943, a next-generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria
C Brunschwig, N Lawrence, D Taylor, E Abay, M Njoroge, GS Basarab, ...
Antimicrobial agents and chemotherapy 62 (9), e00012-18, 2018
302018
Synthesis, characterization and antimalarial activity of new chromium arene–quinoline half sandwich complexes
L Glans, D Taylor, C de Kock, PJ Smith, M Haukka, JR Moss, ...
Journal of inorganic biochemistry 105 (7), 985-990, 2011
302011
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: Part 2
C Le Manach, T Paquet, D Gonzàlez Cabrera, Y Younis, D Taylor, ...
Journal of medicinal chemistry 57 (21), 8839-8848, 2014
292014
Synthesis, characterization, antiparasitic and cytotoxic evaluation of thioureas conjugated to polyamine scaffolds
T Stringer, D Taylor, C de Kock, H Guzgay, A Au, SH An, B Sanchez, ...
European journal of medicinal chemistry 69, 90-98, 2013
282013
Di-and trinuclear ruthenium-, rhodium-, and iridium-functionalized pyridyl aromatic ethers: a new class of antiparasitic agents
P Chellan, KM Land, A Shokar, A Au, SH An, D Taylor, PJ Smith, ...
Organometallics 32 (17), 4793-4804, 2013
272013
A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT
VK Zishiri, R Hunter, PJ Smith, D Taylor, R Summers, K Kirk, RE Martin, ...
European journal of medicinal chemistry 46 (5), 1729-1742, 2011
272011
Reversal of chloroquine resistance in Plasmodium falciparum by 9H-xanthene derivatives
CP Wu, DA van Schalkwyk, D Taylor, PJ Smith, K Chibale
International journal of antimicrobial agents 26 (2), 170-175, 2005
272005
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Articles 1–20