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Dale Taylor
Dale Taylor
Senior Investigator, H3D Drug Discovery Center, University of Cape Town
Verified email at uct.ac.za - Homepage
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Cited by
Cited by
Year
Fate of haem iron in the malaria parasite Plasmodium falciparum.
TJ Egan, JM Combrinck, J Egan, GR Hearne, HM Marques, S Ntenteni, ...
Biochemical Journal 365 (Pt 2), 343, 2002
3912002
Insights into the role of heme in the mechanism of action of antimalarials
JM Combrinck, TE Mabotha, KK Ncokazi, MA Ambele, D Taylor, PJ Smith, ...
ACS chemical biology 8 (1), 133-137, 2013
2752013
Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts
CC Musonda, D Taylor, J Lehman, J Gut, PJ Rosenthal, K Chibale
Bioorganic & medicinal chemistry letters 14 (15), 3901-3905, 2004
1002004
Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration
R van der Westhuyzen, S Winks, CR Wilson, GA Boyle, RK Gessner, ...
Journal of Medicinal Chemistry 58 (23), 9371-9381, 2015
932015
In vitro antimalarial activity, β-haematin inhibition and structure–activity relationships in a series of quinoline triazoles
MC Joshi, KJ Wicht, D Taylor, R Hunter, PJ Smith, TJ Egan
European journal of medicinal chemistry 69, 338-347, 2013
712013
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
J Reader, ME van der Watt, D Taylor, C Le Manach, N Mittal, S Ottilie, ...
Nature communications 12 (1), 269, 2021
672021
UCT943, a next-generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria
C Brunschwig, N Lawrence, D Taylor, E Abay, M Njoroge, GS Basarab, ...
Antimicrobial agents and chemotherapy 62 (9), 10.1128/aac. 00012-18, 2018
622018
Synthesis and evaluation of new polynuclear organometallic Ru (II), Rh (III) and Ir (III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents
P Chellan, KM Land, A Shokar, A Au, SH An, D Taylor, PJ Smith, T Riedel, ...
Dalton Transactions 43 (2), 513-526, 2014
592014
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy
MN Aminake, A Mahajan, V Kumar, R Hans, L Wiesner, D Taylor, ...
Bioorganic & medicinal chemistry 20 (17), 5277-5289, 2012
562012
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1
C Le Manach, D Gonzàlez Cabrera, F Douelle, AT Nchinda, Y Younis, ...
Journal of medicinal chemistry 57 (6), 2789-2798, 2014
542014
Mathematics and science teacher education in South Africa: A review of research, policy and practice in times of change
J Adler, C Pournara, D Taylor, B Thorne, G Moletsane
African Journal of Research in Mathematics, Science and Technology Education …, 2009
532009
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle
C Le Manach, AT Nchinda, T Paquet, D Gonzàlez Cabrera, Y Younis, ...
Journal of medicinal chemistry 59 (21), 9890-9905, 2016
512016
Structure-activity relationship studies of antiplasmodial cyclometallated ruthenium (II), rhodium (III) and iridium (III) complexes of 2-phenylbenzimidazoles
L Rylands, A Welsh, K Maepa, T Stringer, D Taylor, K Chibale, GS Smith
European Journal of Medicinal Chemistry 161, 11-21, 2019
472019
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: Part 2
C Le Manach, T Paquet, D Gonzàlez Cabrera, Y Younis, D Taylor, ...
Journal of medicinal chemistry 57 (21), 8839-8848, 2014
422014
Secondary physical science teachers' conceptions of science teaching in a context of change
DL Taylor, S Booth
International Journal of Science Education 37 (8), 1299-1320, 2015
412015
Di-and trinuclear ruthenium-, rhodium-, and iridium-functionalized pyridyl aromatic ethers: a new class of antiparasitic agents
P Chellan, KM Land, A Shokar, A Au, SH An, D Taylor, PJ Smith, ...
Organometallics 32 (17), 4793-4804, 2013
402013
Synthesis, characterization and antimalarial activity of new chromium arene–quinoline half sandwich complexes
L Glans, D Taylor, C de Kock, PJ Smith, M Haukka, JR Moss, ...
Journal of inorganic biochemistry 105 (7), 985-990, 2011
402011
Heterometallic half-sandwich complexes containing a ferrocenyl motif: Synthesis, molecular structure, electrochemistry and antiplasmodial evaluation
W Nkoana, D Nyoni, P Chellan, T Stringer, D Taylor, PJ Smith, AT Hutton, ...
Journal of Organometallic Chemistry 752, 67-75, 2014
392014
Valuing IKS in successive South African physical sciences curricula
DL Taylor, A Cameron
African Journal of Research in Mathematics, Science and Technology Education …, 2016
382016
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors …
N Kandepedu, D Gonzàlez Cabrera, S Eedubilli, D Taylor, C Brunschwig, ...
Journal of medicinal chemistry 61 (13), 5692-5703, 2018
372018
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