Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ... Nature genetics 45 (12), 1452-1458, 2013 | 4529 | 2013 |
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ... Nature genetics 51 (3), 414-430, 2019 | 2421 | 2019 |
Tau suppression in a neurodegenerative mouse model improves memory function K Santacruz, J Lewis, T Spires, J Paulson, L Kotilinek, M Ingelsson, ... Science 309 (5733), 476-481, 2005 | 2350 | 2005 |
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps A Mahajan, D Taliun, M Thurner, NR Robertson, JM Torres, NW Rayner, ... Nature genetics 50 (11), 1505-1513, 2018 | 1678 | 2018 |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes R Malik, G Chauhan, M Traylor, M Sargurupremraj, Y Okada, A Mishra, ... Nature genetics 50 (4), 524-537, 2018 | 1365 | 2018 |
The Alzheimer's disease-associated amyloid β-protein is an antimicrobial peptide SJ Soscia, JE Kirby, KJ Washicosky, SM Tucker, M Ingelsson, B Hyman, ... PloS one 5 (3), e9505, 2010 | 1293 | 2010 |
New insights into the genetic etiology of Alzheimer’s disease and related dementias C Bellenguez, F Küçükali, IE Jansen, L Kleineidam, S Moreno-Grau, ... Nature genetics 54 (4), 412-436, 2022 | 1238 | 2022 |
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ... Nature genetics 49 (9), 1373-1384, 2017 | 952 | 2017 |
World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions S Kaptoge, L Pennells, D De Bacquer, MT Cooney, M Kavousi, G Stevens, ... The Lancet global health 7 (10), e1332-e1345, 2019 | 943 | 2019 |
Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain M Ingelsson, H Fukumoto, KL Newell, JH Growdon, ET Hedley–Whyte, ... Neurology 62 (6), 925-931, 2004 | 824 | 2004 |
Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers M Sardar Sinha, A Ansell-Schultz, L Civitelli, C Hildesjö, M Larsson, ... Acta neuropathologica 136, 41-56, 2018 | 472 | 2018 |
PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses NG Faux, CW Ritchie, A Gunn, A Rembach, A Tsatsanis, J Bedo, ... Journal of Alzheimer's Disease 20 (2), 509-516, 2010 | 437 | 2010 |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes A Mahajan, J Wessel, SM Willems, W Zhao, NR Robertson, AY Chu, ... Nature genetics 50 (4), 559-571, 2018 | 433 | 2018 |
Alpha-synuclein oligomers—neurotoxic molecules in Parkinson's disease and other Lewy body disorders M Ingelsson Frontiers in neuroscience 10, 408, 2016 | 377 | 2016 |
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation A Mahajan, CN Spracklen, W Zhang, MCY Ng, LE Petty, H Kitajima, ... Nature genetics 54 (5), 560-572, 2022 | 375 | 2022 |
Uniform polarity microtubule assemblies imaged in native brain tissue by second-harmonic generation microscopy DA Dombeck, KA Kasischke, HD Vishwasrao, M Ingelsson, BT Hyman, ... Proceedings of the National Academy of Sciences 100 (12), 7081-7086, 2003 | 365 | 2003 |
High levels of AAV vector integration into CRISPR-induced DNA breaks KS Hanlon, BP Kleinstiver, SP Garcia, MP Zaborowski, A Volak, SE Spirig, ... Nature communications 10 (1), 4439, 2019 | 355 | 2019 |
Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease H Kvartsberg, FH Duits, M Ingelsson, N Andreasen, A Öhrfelt, ... Alzheimer's & Dementia 11 (10), 1180-1190, 2015 | 352 | 2015 |
Consensus guidelines for lumbar puncture in patients with neurological diseases S Engelborghs, E Niemantsverdriet, H Struyfs, K Blennow, R Brouns, ... Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 8, 111-126, 2017 | 347 | 2017 |
Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients JC Watts, C Condello, J Stöhr, A Oehler, J Lee, SJ DeArmond, L Lannfelt, ... Proceedings of the National Academy of Sciences 111 (28), 10323-10328, 2014 | 330 | 2014 |