Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4 HS Kuehn, W Ouyang, B Lo, EK Deenick, JE Niemela, DT Avery, ... Science 345 (6204), 1623-1627, 2014 | 884 | 2014 |
Dominant-activating germline mutations in the gene encoding the PI (3) K catalytic subunit p110δ result in T cell senescence and human immunodeficiency CL Lucas, HS Kuehn, F Zhao, JE Niemela, EK Deenick, U Palendira, ... Nature immunology 15 (1), 88-97, 2014 | 829 | 2014 |
The origins, function, and regulation of T follicular helper cells CS Ma, EK Deenick, M Batten, SG Tangye Journal of Experimental Medicine 209 (7), 1241-1253, 2012 | 710 | 2012 |
The good, the bad and the ugly — TFH cells in human health and disease SG Tangye, CS Ma, R Brink, EK Deenick Nature Reviews Immunology 13 (6), 412-426, 2013 | 619 | 2013 |
B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans DT Avery, EK Deenick, CS Ma, S Suryani, N Simpson, GY Chew, ... Journal of Experimental Medicine 207 (1), 155-171, 2010 | 439 | 2010 |
Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations S Okada, JG Markle, EK Deenick, F Mele, D Averbuch, M Lagos, ... Science 349 (6248), 606-613, 2015 | 419 | 2015 |
Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL‐12 CS Ma, S Suryani, DT Avery, A Chan, R Nanan, B Santner‐Nanan, ... Immunology and cell biology 87 (8), 590-600, 2009 | 391 | 2009 |
Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling EK Deenick, A Chan, CS Ma, D Gatto, PL Schwartzberg, R Brink, ... Immunity 33 (2), 241-253, 2010 | 379 | 2010 |
Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses SG Tangye, DT Avery, EK Deenick, PD Hodgkin The Journal of Immunology 170 (2), 686-694, 2003 | 371 | 2003 |
Functional STAT3 deficiency compromises the generation of human T follicular helper cells CS Ma, DT Avery, A Chan, M Batten, J Bustamante, S Boisson-Dupuis, ... Blood, The Journal of the American Society of Hematology 119 (17), 3997-4008, 2012 | 343 | 2012 |
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production KL Randall, T Lambe, AL Johnson, B Treanor, E Kucharska, ... Nature immunology 10 (12), 1283-1291, 2009 | 305 | 2009 |
Human T follicular helper (Tfh) cells and disease CS Ma, EK Deenick Immunology and cell biology 92 (1), 64-71, 2014 | 235 | 2014 |
Stochastic model of T cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival EK Deenick, AV Gett, PD Hodgkin The Journal of Immunology 170 (10), 4963-4972, 2003 | 200 | 2003 |
Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells EK Deenick, DT Avery, A Chan, LJ Berglund, ML Ives, L Moens, ... Journal of Experimental Medicine 210 (12), 2739-2753, 2013 | 198 | 2013 |
Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies CS Ma, N Wong, G Rao, DT Avery, J Torpy, T Hambridge, J Bustamante, ... Journal of Allergy and Clinical Immunology 136 (4), 993-1006. e1, 2015 | 197 | 2015 |
T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses D Suan, A Nguyen, I Moran, K Bourne, JR Hermes, M Arshi, HR Hampton, ... Immunity 42 (4), 704-718, 2015 | 197 | 2015 |
Quantitative analysis of lymphocyte differentiation and proliferation in vitro using carboxyfluorescein diacetate succinimidyl ester J Hasbold, AV Gett, JS Rush, E Deenick, D Avery, J Jun, PD Hodgkin Immunology and cell biology 77 (6), 516-522, 1999 | 188 | 1999 |
TCR affinity and negative regulation limit autoimmunity MA Gronski, JM Boulter, D Moskophidis, LT Nguyen, K Holmberg, ... Nature medicine 10 (11), 1234-1239, 2004 | 180 | 2004 |
Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation EK Deenick, J Hasbold, PD Hodgkin The Journal of immunology 163 (9), 4707-4714, 1999 | 176 | 1999 |
Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23 R Martínez-Barricarte, JG Markle, CS Ma, EK Deenick, N Ramírez-Alejo, ... Science immunology 3 (30), eaau6759, 2018 | 173 | 2018 |