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Jacques Deguine
Jacques Deguine
Scientific Director, Immunology, Broad Institute
Verified email at broadinstitute.org
Title
Cited by
Cited by
Year
MyD88: a central player in innate immune signaling
J Deguine, GM Barton
F1000Prime Reports 6, 2014
6642014
A map of toll-like receptor expression in the intestinal epithelium reveals distinct spatial, cell type-specific, and temporal patterns
AE Price, K Shamardani, KA Lugo, J Deguine, AW Roberts, BL Lee, ...
Immunity 49 (3), 560-575. e6, 2018
3232018
Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells
AW Roberts, BL Lee, J Deguine, S John, MJ Shlomchik, GM Barton
Immunity 47 (5), 913-927. e6, 2017
2562017
The mechanism of anti-CD20–mediated B cell depletion revealed by intravital imaging
F Montalvao, Z Garcia, S Celli, B Breart, J Deguine, N Van Rooijen, ...
The Journal of clinical investigation 123 (12), 5098-5103, 2013
2062013
Intravital imaging reveals distinct dynamics for natural killer and CD8+ T cells during tumor regression
J Deguine, B Breart, F Lemaître, JP Di Santo, P Bousso
Immunity 33 (4), 632-644, 2010
1952010
Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis
CM Walsh, RZ Hill, J Schwendinger-Schreck, J Deguine, EC Brock, ...
Elife 8, e48448, 2019
1242019
Visualizing the functional diversification of CD8+ T cell responses in lymph nodes
H Beuneu, F Lemaître, J Deguine, HD Moreau, I Bouvier, Z Garcia, ...
Immunity 33 (3), 412-423, 2010
922010
B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV
JF Scheid, CO Barnes, B Eraslan, A Hudak, JR Keeffe, LA Cosimi, ...
Cell 184 (12), 3205-3221. e24, 2021
912021
Dynamic behavior of NK cells during activation in lymph nodes
H Beuneu, J Deguine, B Breart, O Mandelboim, JP Di Santo, P Bousso
Blood, The Journal of the American Society of Hematology 114 (15), 3227-3234, 2009
802009
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon
L Kong, V Pokatayev, A Lefkovith, GT Carter, EA Creasey, C Krishna, ...
Immunity 56 (2), 444-458. e5, 2023
762023
Cutting Edge: Tumor-Targeting Antibodies Enhance NKG2D-Mediated NK Cell Cytotoxicity by Stabilizing NK Cell–Tumor Cell Interactions
J Deguine, B Breart, F Lemaître, P Bousso
The Journal of Immunology 189 (12), 5493-5497, 2012
472012
Dynamics of NK cell interactions in vivo
J Deguine, P Bousso
Immunological reviews 251 (1), 154-159, 2013
412013
A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma
J Alladina, NP Smith, T Kooistra, K Slowikowski, IJ Kernin, J Deguine, ...
Science Immunology 8 (83), eabq6352, 2023
392023
Cutting Edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation
H Beuneu, J Deguine, I Bouvier, JP Di Santo, ML Albert, P Bousso
The Journal of Immunology 187 (5), 2084-2088, 2011
362011
Local TNFR1 Signaling Licenses Murine Neutrophils for Increased TLR-Dependent Cytokine and Eicosanoid Production
J Deguine, J Wei, R Barbalat, K Gronert, GM Barton
The Journal of Immunology 198 (7), 2865-2875, 2017
142017
A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells
A Ulezko Antonova, S Lonardi, M Monti, F Missale, C Fan, ML Coates, ...
Proceedings of the National Academy of Sciences 120 (52), e2318710120, 2023
112023
Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production
J Xu, L Kong, BA Oliver, B Li, EA Creasey, G Guzman, M Schenone, ...
Cell Reports 42 (7), 2023
112023
An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission
J Ding, JJ Garber, A Uchida, A Lefkovith, GT Carter, P Vimalathas, ...
Nature Communications 15 (1), 3344, 2024
82024
No antigen-presentation defect in Unc93b13d/3d (3d) mice
J Deguine, BL Lee, ZR Newman, GM Barton
Nature immunology 14 (11), 1101-1102, 2013
82013
Remodeling of colon plasma cell repertoire within ulcerative colitis patients
JF Scheid, B Eraslan, A Hudak, EM Brown, D Sergio, TM Delorey, ...
Journal of Experimental Medicine 220 (4), e20220538, 2023
72023
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