| Type IIA topoisomerase inhibition by a new class of antibacterial agents BD Bax, PF Chan, DS Eggleston, A Fosberry, DR Gentry, F Gorrec, ... Nature 466 (7309), 935-940, 2010 | 823 | 2010 |
| Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance A Wohlkonig, PF Chan, AP Fosberry, P Homes, J Huang, M Kranz, ... Nature structural & molecular biology 17 (9), 1152-1153, 2010 | 335 | 2010 |
| Role of SarA in Virulence Determinant Production and Environmental Signal Transduction in Staphylococcus aureus PF Chan, SJ Foster Journal of bacteriology 180 (23), 6232-6241, 1998 | 324 | 1998 |
| The Staphylococcus aureus Alternative Sigma Factor ςB Controls the Environmental Stress Response but Not Starvation Survival or Pathogenicity in a Mouse … PF Chan, SJ Foster, E Ingham, MO Clements Journal of bacteriology 180 (23), 6082-6089, 1998 | 274 | 1998 |
| The role of environmental factors in the regulation of virulence-determinant expression in Staphylococcus aureus 8325-4 PF Chan, SJ Foster Microbiology 144 (9), 2469-2479, 1998 | 163 | 1998 |
| Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase EG Gibson, B Bax, PF Chan, N Osheroff ACS infectious diseases 5 (4), 570-581, 2019 | 118 | 2019 |
| Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin PF Chan, V Srikannathasan, J Huang, H Cui, AP Fosberry, M Gu, ... Nature communications 6 (1), 10048, 2015 | 118 | 2015 |
| Characterization of a novel fucose-regulated promoter (P fcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae PF Chan, KM O'Dwyer, LM Palmer, JD Ambrad, KA Ingraham, C So, ... Journal of bacteriology 185 (6), 2051-2058, 2003 | 117 | 2003 |
| Staphylococcus aureus accessory regulators: expression within biofilms and effect on adhesion J Pratten, SJ Foster, PF Chan, M Wilson, SP Nair Microbes and infection 3 (8), 633-637, 2001 | 94 | 2001 |
| Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening CA Machutta, CS Kollmann, KE Lind, X Bai, PF Chan, J Huang, L Ballell, ... Nature communications 8 (1), 16081, 2017 | 73 | 2017 |
| Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase PF Chan, T Germe, BD Bax, J Huang, RK Thalji, E Bacqué, A Checchia, ... Proceedings of the National Academy of Sciences 114 (22), E4492-E4500, 2017 | 70 | 2017 |
| Novel antibacterials: a genomics approach to drug discovery PF Chan, R Macarron, DJ Payne, M Zalacain, DJ Holmes Current Drug Targets-Infectious Disorders 2 (4), 291-308, 2002 | 62 | 2002 |
| Finding the gems using genomic discovery: antibacterial drug discovery strategies–the successes and the challenges PF Chan, DJ Holmes, DJ Payne Drug Discovery Today: Therapeutic Strategies 1 (4), 519-527, 2004 | 60 | 2004 |
| Stability of silica packing materials towards a mixed aqueous-organic eluent at alkaline pH B Law, PF Chan Journal of Chromatography A 467, 267-271, 1989 | 43 | 1989 |
| Structure-guided design of antibacterials that allosterically inhibit DNA gyrase RK Thalji, K Raha, D Andreotti, A Checchia, H Cui, G Meneghelli, ... Bioorganic & Medicinal Chemistry Letters 29 (11), 1407-1412, 2019 | 22 | 2019 |
| Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide V Srikannathasan, A Wohlkonig, A Shillings, O Singh, PF Chan, J Huang, ... Acta Crystallographica Section F: Structural Biology Communications 71 (10 …, 2015 | 21 | 2015 |
| Bimodal actions of a naphthyridone/aminopiperidine-based antibacterial that targets gyrase and topoisomerase IV EG Gibson, AA Oviatt, M Cacho, KC Neuman, PF Chan, N Osheroff Biochemistry 58 (44), 4447-4455, 2019 | 18 | 2019 |
| Recent developments in inhibitors of bacterial type IIA topoisomerases PF Chan, J Huang, BD Bax, MN Gwynn Antibiotics: targets, mechanisms and resistance, 263-297, 2013 | 16 | 2013 |
| High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay PK Singh, PF Chan, MJ Hibbs, MJ Vazquez, DC Segura, DA Thomas, ... Protein expression and purification 76 (2), 165-172, 2011 | 14 | 2011 |
| Possible role for stationary phase metal interactions in the chromatography of hydroxyamines on silica B Law, PF Chan Journal of Chromatography A 552, 429-438, 1991 | 8 | 1991 |
