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Kathryn Wicht
Kathryn Wicht
Research Officer, University of Cape Town, South Africa
Verified email at uct.ac.za
Title
Cited by
Cited by
Year
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
LS Ross, SK Dhingra, S Mok, T Yeo, KJ Wicht, K Kümpornsin, ...
Nature communications 9 (1), 1-13, 2018
1362018
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT
J Kim, YZ Tan, KJ Wicht, SK Erramilli, SK Dhingra, J Okombo, J Vendome, ...
Nature 576 (7786), 315-320, 2019
802019
In vitro antimalarial activity, β-haematin inhibition and structure–activity relationships in a series of quinoline triazoles
MC Joshi, KJ Wicht, D Taylor, R Hunter, PJ Smith, TJ Egan
European journal of medicinal chemistry 69, 338-347, 2013
582013
Synthesis and antimalarial testing of neocryptolepine analogues: Addition of ester function in SAR study of 2, 11-disubstituted indolo [2, 3-b] quinolines
WJ Lu, KJ Wicht, L Wang, K Imai, ZW Mei, M Kaiser, IET El Sayed, ...
European journal of medicinal chemistry 64, 498-511, 2013
552013
Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
KJ Wicht, S Mok, DA Fidock
Annual review of microbiology 74, 431-454, 2020
542020
Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo [3, 2-c] quinolines with various substituents at C2, C6 …
N Wang, KJ Wicht, K Imai, M Wang, TA Ngoc, R Kiguchi, M Kaiser, ...
Bioorganic & medicinal chemistry 22 (9), 2629-2642, 2014
532014
Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity
RD Sandlin, KY Fong, KJ Wicht, HM Carrell, TJ Egan, DW Wright
International Journal for Parasitology: Drugs and Drug Resistance 4 (3), 316-325, 2014
472014
Synthesis and evaluation of artesunate–indoloquinoline hybrids as antimalarial drug candidates
N Wang, KJ Wicht, E Shaban, TA Ngoc, MQ Wang, I Hayashi, MI Hossain, ...
MedChemComm 5 (7), 927-931, 2014
412014
Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity
R Raj, V Mehra, J Gut, PJ Rosenthal, KJ Wicht, TJ Egan, M Hopper, ...
European Journal of Medicinal Chemistry 84, 425-432, 2014
362014
Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity
M Vanaerschot, JM Murithi, CFA Pasaje, S Ghidelli-Disse, L Dwomoh, ...
Cell chemical biology 27 (7), 806-816. e8, 2020
312020
Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains
M Chugh, C Scheurer, S Sax, E Bilsland, DA van Schalkwyk, KJ Wicht, ...
Antimicrobial agents and chemotherapy 59 (2), 1110-1118, 2015
282015
Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum
KJ Wicht, JM Combrinck, PJ Smith, R Hunter, TJ Egan
Journal of medicinal chemistry 59 (13), 6512-6530, 2016
242016
Antimalarial benzoheterocyclic 4-aminoquinolines: structure–activity relationship, in vivo evaluation, mechanistic and bioactivation studies
DSB Ongarora, N Strydom, K Wicht, M Njoroge, L Wiesner, TJ Egan, ...
Bioorganic & medicinal chemistry 23 (17), 5419-5432, 2015
232015
Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity
KJ Wicht, JM Combrinck, PJ Smith, TJ Egan
Bioorganic & medicinal chemistry 23 (16), 5210-5217, 2015
172015
Synthesis and in vitro testing of antimalarial activity of non-natural-type neocryptolepines: structure–activity relationship study of 2, 11-and 9, 11-disubstituted 6 …
N Wang, KJ Wicht, L Wang, WJ Lu, R Misumi, M Wang, AAA El Gokha, ...
Chemical and pharmaceutical bulletin 61 (12), 1282-1290, 2013
162013
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine. Nat Commun 9: 3314
LS Ross, SK Dhingra, S Mok, T Yeo, KJ Wicht, K Kümpornsin, ...
152018
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγnull Mouse …
AT Nchinda, C Le Manach, T Paquet, D Gonzàlez Cabrera, KJ Wicht, ...
Journal of medicinal chemistry 61 (9), 4213-4227, 2018
142018
Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum
KJ Wicht, JM Combrinck, PJ Smith, R Hunter, TJ Egan
ACS medicinal chemistry letters 8 (2), 201-205, 2017
142017
N10, N11-di-alkylamine indolo [3, 2-b] quinolines as hemozoin inhibitors: Design, synthesis and antiplasmodial activity
M Figueiras, L Coelho, KJ Wicht, SA Santos, J Lavrado, J Gut, ...
Bioorganic & Medicinal Chemistry 23 (7), 1530-1539, 2015
142015
Antimalarial lead-optimization studies on a 2, 6-imidazopyridine series within a constrained chemical space to circumvent atypical dose–response curves against multidrug …
C Le Manach, T Paquet, K Wicht, AT Nchinda, C Brunschwig, M Njoroge, ...
Journal of medicinal chemistry 61 (20), 9371-9385, 2018
102018
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