| Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine LS Ross, SK Dhingra, S Mok, T Yeo, KJ Wicht, K Kümpornsin, ... Nature communications 9 (1), 3314, 2018 | 204 | 2018 |
| Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria KJ Wicht, S Mok, DA Fidock Annual review of microbiology 74, 431-454, 2020 | 170 | 2020 |
| Structure and drug resistance of the Plasmodium falciparum transporter PfCRT J Kim, YZ Tan, KJ Wicht, SK Erramilli, SK Dhingra, J Okombo, J Vendome, ... Nature 576 (7786), 315-320, 2019 | 154 | 2019 |
| In vitro antimalarial activity, β-haematin inhibition and structure–activity relationships in a series of quinoline triazoles MC Joshi, KJ Wicht, D Taylor, R Hunter, PJ Smith, TJ Egan European journal of medicinal chemistry 69, 338-347, 2013 | 71 | 2013 |
| Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo [3, 2-c] quinolines with various substituents at C2, C6 … N Wang, KJ Wicht, K Imai, M Wang, TA Ngoc, R Kiguchi, M Kaiser, ... Bioorganic & medicinal chemistry 22 (9), 2629-2642, 2014 | 67 | 2014 |
| Synthesis and antimalarial testing of neocryptolepine analogues: Addition of ester function in SAR study of 2, 11-disubstituted indolo [2, 3-b] quinolines WJ Lu, KJ Wicht, L Wang, K Imai, ZW Mei, M Kaiser, IET El Sayed, ... European journal of medicinal chemistry 64, 498-511, 2013 | 67 | 2013 |
| Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity M Vanaerschot, JM Murithi, CFA Pasaje, S Ghidelli-Disse, L Dwomoh, ... Cell chemical biology 27 (7), 806-816. e8, 2020 | 61 | 2020 |
| Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity RD Sandlin, KY Fong, KJ Wicht, HM Carrell, TJ Egan, DW Wright International Journal for Parasitology: Drugs and Drug Resistance 4 (3), 316-325, 2014 | 53 | 2014 |
| Synthesis and evaluation of artesunate–indoloquinoline hybrids as antimalarial drug candidates N Wang, KJ Wicht, E Shaban, TA Ngoc, MQ Wang, I Hayashi, MI Hossain, ... MedChemComm 5 (7), 927-931, 2014 | 49 | 2014 |
| Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity R Raj, V Mehra, J Gut, PJ Rosenthal, KJ Wicht, TJ Egan, M Hopper, ... European Journal of Medicinal Chemistry 84, 425-432, 2014 | 43 | 2014 |
| Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains M Chugh, C Scheurer, S Sax, E Bilsland, DA van Schalkwyk, KJ Wicht, ... Antimicrobial agents and chemotherapy 59 (2), 1110-1118, 2015 | 40 | 2015 |
| Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum KJ Wicht, JM Combrinck, PJ Smith, R Hunter, TJ Egan Journal of medicinal chemistry 59 (13), 6512-6530, 2016 | 29 | 2016 |
| Antimalarial benzoheterocyclic 4-aminoquinolines: structure–activity relationship, in vivo evaluation, mechanistic and bioactivation studies DSB Ongarora, N Strydom, K Wicht, M Njoroge, L Wiesner, TJ Egan, ... Bioorganic & medicinal chemistry 23 (17), 5419-5432, 2015 | 29 | 2015 |
| Synthesis and in vitro testing of antimalarial activity of non-natural-type neocryptolepines: Structure–activity relationship study of 2, 11-and 9, 11-disubstituted 6 … N Wang, KJ Wicht, L Wang, WJ Lu, R Misumi, M Wang, AAA El Gokha, ... Chemical and pharmaceutical bulletin 61 (12), 1282-1290, 2013 | 24 | 2013 |
| Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγnull Mouse … AT Nchinda, C Le Manach, T Paquet, D Gonzàlez Cabrera, KJ Wicht, ... Journal of medicinal chemistry 61 (9), 4213-4227, 2018 | 22 | 2018 |
| Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity KJ Wicht, JM Combrinck, PJ Smith, TJ Egan Bioorganic & medicinal chemistry 23 (16), 5210-5217, 2015 | 22 | 2015 |
| Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine. Nat Commun 9: 3314 LS Ross, SK Dhingra, S Mok, T Yeo, KJ Wicht, K Kümpornsin, ... | 21 | 2018 |
| N10, N11-di-alkylamine indolo [3, 2-b] quinolines as hemozoin inhibitors: Design, synthesis and antiplasmodial activity M Figueiras, L Coelho, KJ Wicht, SA Santos, J Lavrado, J Gut, ... Bioorganic & Medicinal Chemistry 23 (7), 1530-1539, 2015 | 18 | 2015 |
| Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials KJ Wicht, JL Small-Saunders, LM Hagenah, S Mok, DA Fidock The Journal of Infectious Diseases 226 (11), 2021-2029, 2022 | 17 | 2022 |
| The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance JM Murithi, I Deni, CFA Pasaje, J Okombo, JL Bridgford, NF Gnädig, ... Cell chemical biology 29 (5), 824-839. e6, 2022 | 17 | 2022 |
