| Cell cycle proteins as promising targets in cancer therapy T Otto, P Sicinski Nature Reviews Cancer 17 (2), 93-115, 2017 | 1740 | 2017 |
| Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma T Otto, S Horn, M Brockmann, U Eilers, L Schüttrumpf, N Popov, ... Cancer cell 15 (1), 67-78, 2009 | 621 | 2009 |
| MYCN regulates oncogenic MicroRNAs in neuroblastoma JH Schulte, S Horn, T Otto, B Samans, LC Heukamp, UC Eilers, M Krause, ... International journal of cancer 122 (3), 699-704, 2008 | 306 | 2008 |
| Cyclin C is a haploinsufficient tumour suppressor N Li, A Fassl, J Chick, H Inuzuka, X Li, MR Mansour, L Liu, H Wang, ... Nature cell biology 16 (11), 1080-1091, 2014 | 159 | 2014 |
| The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenance J Van Riggelen, J Müller, T Otto, V Beuger, A Yetil, PS Choi, C Kosan, ... Genes & development 24 (12), 1281-1294, 2010 | 136 | 2010 |
| Updates on the CDK4/6 inhibitory strategy and combinations in breast cancer N Sobhani, A D’Angelo, M Pittacolo, G Roviello, A Miccoli, SP Corona, ... Cells 8 (4), 321, 2019 | 129 | 2019 |
| Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis A Mohs, T Otto, KM Schneider, M Peltzer, M Boekschoten, CH Holland, ... Journal of hepatology 74 (3), 638-648, 2021 | 98 | 2021 |
| Cell-cycle-targeting MicroRNAs as therapeutic tools against refractory cancers P Hydbring, Y Wang, A Fassl, X Li, V Matia, T Otto, YJ Choi, KE Sweeney, ... Cancer cell 31 (4), 576-590. e8, 2017 | 95 | 2017 |
| Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit T Otto, SV Candido, MS Pilarz, E Sicinska, RT Bronson, M Bowden, ... Proceedings of the National Academy of Sciences 114 (40), 10660-10665, 2017 | 91 | 2017 |
| Cdk1 controls global epigenetic landscape in embryonic stem cells W Michowski, JM Chick, C Chu, A Kolodziejczyk, Y Wang, JM Suski, ... Molecular cell 78 (3), 459-476. e13, 2020 | 90 | 2020 |
| Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition A Fassl, C Brain, M Abu-Remaileh, I Stukan, D Butter, P Stepien, AS Feit, ... Science advances 6 (25), eabb2210, 2020 | 50 | 2020 |
| Targeting aberrant FGFR signaling to overcome CDK4/6 inhibitor resistance in breast cancer N Sobhani, A Fassl, G Mondani, D Generali, T Otto Cells 10 (2), 293, 2021 | 34 | 2021 |
| ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression J Grube, MM Woitok, A Mohs, S Erschfeld, C Lynen, C Trautwein, T Otto Cell death & disease 13 (8), 704, 2022 | 29 | 2022 |
| The kinase-independent, second life of CDK6 in transcription T Otto, P Sicinski Cancer Cell 24 (2), 141-143, 2013 | 26 | 2013 |
| Myeloid cells require gp130 signaling for protective anti‐inflammatory functions during sepsis SD Sackett, T Otto, A Mohs, LE Sander, S Strauch, KL Streetz, DC Kroy, ... The FASEB Journal 33 (5), 6035-6044, 2019 | 17 | 2019 |
| MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis A Mohs, N Kuttkat, T Otto, SA Youssef, A De Bruin, C Trautwein Carcinogenesis 41 (2), 171-181, 2020 | 14 | 2020 |
| NLRP6 inflammasome modulates disease progression in a chronic-plus-binge mouse model of alcoholic liver disease RE Mainz, S Albers, M Haque, R Sonntag, NS Treichel, T Clavel, E Latz, ... Cells 11 (2), 182, 2022 | 13 | 2022 |
| MYCN and its Posttranslational Regulation in Neuroblastoma T Otto Progressive Neuroblastoma 20, 47-58, 2015 | 4 | 2015 |
| Expression of Cyclin E1 in hepatic stellate cells is critical for the induction and progression of liver fibrosis and hepatocellular carcinoma in mice J Otto, A Verwaayen, C Penners, J Hundertmark, C Lin, C Kallen, ... Cell Death & Disease 14 (8), 549, 2023 | 1 | 2023 |
| Unexpected function of the cell cycle kinase Cyclin E/CDK2 for control of intestinal barrier: implications for gut-liver communication, liver fibrosis and liver cancer A Verwaayen, J Hennings, C Penners, A Guillot, T Otto, N Treichel, ... Journal of Hepatology 78, S24, 2023 | | 2023 |
Birgit SamansTechnische Hochschule Mittelhessen/Faculty of Health SciencesVerified email at ges.thm.de
