Bcl-2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose-dependent toxicity and resistance G Leisching, B Loos, M Botha, AM Engelbrecht Journal of translational medicine 13, 1-8, 2015 | 48 | 2015 |
Comparison of human monocyte derived macrophages and THP1-like macrophages as in vitro models for M. tuberculosis infection A Madhvi, H Mishra, GR Leisching, PZ Mahlobo, B Baker Comparative immunology, microbiology and infectious diseases 67, 101355, 2019 | 47 | 2019 |
The association of OASL and type I interferons in the pathogenesis and survival of intracellular replicating bacterial species G Leisching, I Wiid, B Baker Frontiers in cellular and infection microbiology 7, 196, 2017 | 45 | 2017 |
OAS1, OAS2 and OAS3 restrict intracellular M. tb replication and enhance cytokine secretion G Leisching, V Cole, AT Ali, B Baker International journal of infectious diseases 80, S77-S84, 2019 | 42 | 2019 |
The role of mTOR during cisplatin treatment in an in vitro and ex vivo model of cervical cancer GR Leisching, B Loos, MH Botha, AM Engelbrecht Toxicology 335, 72-78, 2015 | 39 | 2015 |
The host response to a clinical MDR mycobacterial strain cultured in a detergent-free environment: a global transcriptomics approach G Leisching, RD Pietersen, V Mpongoshe, C Van Heerden, P Van Helden, ... PLoS One 11 (4), e0153079, 2016 | 37 | 2016 |
RNAseq reveals hypervirulence-specific host responses to M. tuberculosis infection G Leisching, RD Pietersen, C van Heerden, P van Helden, I Wiid, B Baker Virulence 8 (6), 848-858, 2017 | 26 | 2017 |
OAS1, 2, and 3: significance during active tuberculosis? G Leisching, I Wiid, B Baker The Journal of infectious diseases 217 (10), 1517-1521, 2018 | 25 | 2018 |
A nontoxic concentration of cisplatin induces autophagy in cervical cancer: selective cancer cell death with autophagy inhibition as an adjuvant treatment G Leisching, B Loos, M Botha, AM Engelbrecht International Journal of Gynecologic Cancer 25 (3), 2015 | 25 | 2015 |
Virulence, biochemistry, morphology and host-interacting properties of detergent-free cultured mycobacteria: An update G Leisching, RD Pietersen, I Wiid, B Baker Tuberculosis 100, 53-60, 2016 | 23 | 2016 |
Lactate Alters Metabolism in Human Macrophages and Improves Their Ability to Kill Mycobacterium tuberculosis C Ó Maoldomhnaigh, DJ Cox, JJ Phelan, M Mitermite, DM Murphy, ... Frontiers in Immunology 12, 663695, 2021 | 22 | 2021 |
Tween 80 induces a carbon flux rerouting in Mycobacterium tuberculosis RD Pietersen, I Du Preez, M van Reenen, D Beukes, G Leisching, ... Journal of microbiological methods 170, 105795, 2020 | 22 | 2020 |
Susceptibility to tuberculosis is associated with PI3K-dependent increased mobilization of neutrophils GR Leisching Frontiers in Immunology 9, 386122, 2018 | 19 | 2018 |
Sutherlandia frutescens treatment induces apoptosis and modulates the PI3-kinase pathway in colon cancer cells G Leisching, B Loos, T Nell, AM Engelbrecht South African Journal of Botany 100, 20-26, 2015 | 19 | 2015 |
2′-5′-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion G Leisching, A Ali, V Cole, B Baker Molecular immunology 118, 73-78, 2020 | 17 | 2020 |
Distinct host-immune response toward species related intracellular mycobacterial killing: A transcriptomic study A Madhvi, H Mishra, NN Chegou, G Tromp, CJ Van Heerden, ... Virulence 11 (1), 170-182, 2020 | 11 | 2020 |
Mitochondrial bioenergetic changes in systemic lupus erythematosus immune cell subsets: Contributions to pathogenesis and clinical applications AS Yennemadi, J Keane, G Leisching Lupus 32 (5), 603-611, 2023 | 5 | 2023 |
Immunoglobulin profile and B‐cell frequencies are altered with changes in the cellular microenvironment independent of the stimulation conditions DK Moore, GR Leisching, CI Snyders, A Gutschmidt, IC van Rensburg, ... Immunity, Inflammation and Disease 8 (3), 458-467, 2020 | 4 | 2020 |
PI3-kinase δγ catalytic isoforms regulate the Th-17 response in tuberculosis GR Leisching Frontiers in Immunology 10, 479442, 2019 | 3 | 2019 |
Chronic IFNα treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring AS Yennemadi, G Jameson, M Glass, C De Pasquale, J Keane, M Bianchi, ... Cellular Immunology 390, 104741, 2023 | 2 | 2023 |