Ryan Hlady
Ryan Hlady
Assistant Professor, Mayo Clinic
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Immature truncated O-glycophenotype of cancer directly induces oncogenic features
P Radhakrishnan, S Dabelsteen, FB Madsen, C Francavilla, KL Kopp, ...
Proceedings of the National Academy of Sciences 111 (39), E4066-E4075, 2014
Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues
D Zhou, BM Alver, S Li, RA Hlady, JJ Thompson, MA Schroeder, JH Lee, ...
Genome biology 19 (1), 1-25, 2018
Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis
RA Hlady, S Novakova, J Opavska, D Klinkebiel, SL Peters, J Bies, ...
The Journal of clinical investigation 122 (1), 163-177, 2012
Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis
RA Hlady, RL Tiedemann, W Puszyk, I Zendejas, LR Roberts, JH Choi, ...
Oncotarget 5 (19), 9425, 2014
DNA methylation age is accelerated in alcohol dependence
AD Rosen, KD Robertson, RA Hlady, C Muench, J Lee, R Philibert, ...
Translational psychiatry 8 (1), 1-8, 2018
Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas
SL Peters, RA Hlady, J Opavska, D Klinkebiel, S Novakova, LM Smith, ...
Molecular and cellular biology 33 (21), 4321-4333, 2013
Integrating the epigenome to identify drivers of hepatocellular carcinoma
RA Hlady, A Sathyanarayan, JJ Thompson, D Zhou, Q Wu, K Pham, ...
Hepatology 69 (2), 639-652, 2019
Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis
SL Peters, RA Hlady, J Opavska, D Klinkebiel, SJ Pirruccello, GA Talmon, ...
Leukemia 28 (5), 1138-1142, 2014
Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma
RL Tiedemann, RA Hlady, PD Hanavan, DF Lake, R Tibes, JH Lee, ...
Oncotarget 7 (2), 1927, 2016
Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome
RL Tiedemann, EL Putiri, JH Lee, RA Hlady, K Kashiwagi, T Ordog, ...
Cell reports 9 (4), 1554-1566, 2014
Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA
RA Hlady, X Zhao, X Pan, JD Yang, F Ahmed, SO Antwi, NH Giama, ...
Theranostics 9 (24), 7239, 2019
High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver
D Zhou, RA Hlady, MJ Schafer, TA White, C Liu, JH Choi, JD Miller, ...
Epigenetics 12 (1), 55-69, 2017
Promoter hypomethylation and expression is conserved in mouse chronic lymphocytic leukemia induced by decreased or inactivated Dnmt3a
SL Haney, GM Upchurch, J Opavska, D Klinkebiel, RA Hlady, A Suresh, ...
Cell reports 15 (6), 1190-1201, 2016
Dnmt3a is a haploinsufficient tumor suppressor in CD8+ peripheral T cell lymphoma
SL Haney, GM Upchurch, J Opavska, D Klinkebiel, RA Hlady, S Roy, ...
PLoS genetics 12 (9), e1006334, 2016
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis
SL Haney, RA Hlady, J Opavska, D Klinkebiel, SJ Pirruccello, S Dutta, ...
Oncogene 34 (43), 5436-5446, 2015
Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer
RA Hlady, D Zhou, W Puszyk, LR Roberts, C Liu, KD Robertson
Epigenetics 12 (3), 215-225, 2017
DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma
Y Zheng, RA Hlady, BT Joyce, KD Robertson, C He, DR Nannini, ...
Clinical epigenetics 11 (1), 1-13, 2019
Alpha‐1 antitrypsin deficiency liver disease, mutational homogeneity modulated by epigenetic heterogeneity with links to obesity
L Wang, GW Marek III, RA Hlady, RT Wagner, X Zhao, VC Clark, AX Fan, ...
Hepatology 70 (1), 51-66, 2019
Genetic and epigenetic heterogeneity in normal liver homeostasis and its implications for liver disease and hepatocellular cancer
RA Hlady, KD Robertson
Seminars in liver disease 38 (01), 041-050, 2018
Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions
P Nowialis, K Lopusna, J Opavska, SL Haney, A Abraham, P Sheng, ...
Nature communications 10 (1), 1-16, 2019
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