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Lloyd Czaplewski
Lloyd Czaplewski
Unknown affiliation
Verified email at chembioventures.com
Title
Cited by
Cited by
Year
Alternatives to antibiotics—a pipeline portfolio review
L Czaplewski, R Bax, M Clokie, M Dawson, H Fairhead, VA Fischetti, ...
The Lancet infectious diseases 16 (2), 239-251, 2016
8902016
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity
DJ Haydon, NR Stokes, R Ure, G Galbraith, JM Bennett, DR Brown, ...
Science 321 (5896), 1673-1675, 2008
4952008
Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement
I Chopra, C Schofield, M Everett, A O'Neill, K Miller, M Wilcox, JM Frère, ...
The Lancet infectious diseases 8 (2), 133-139, 2008
3392008
Discovery research: the scientific challenge of finding new antibiotics
DM Livermore, ...
Journal of antimicrobial chemotherapy 66 (9), 1941-1944, 2011
3362011
Discovery and development of new antibacterial drugs: learning from experience?
N Jackson, L Czaplewski, LJV Piddock
Journal of Antimicrobial Chemotherapy 73 (6), 1452-1459, 2018
2482018
Analysis of the clinical antibacterial and antituberculosis pipeline
U Theuretzbacher, S Gottwalt, P Beyer, M Butler, L Czaplewski, ...
The Lancet Infectious Diseases 19 (2), e40-e50, 2019
2272019
Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES: characterization of active …
LG Czaplewski, J McKeating, CJ Craven, LD Higgins, V Appay, A Brown, ...
Journal of Biological Chemistry 274 (23), 16077-16084, 1999
2171999
Mobilization of early hematopoietic progenitor cells with BB-10010: A genetically engineered variant of human macrophage inflammatory protein-la
BI Lord, LB Woolford, LM Wood, LG Czaplewski, M McCourt, MG Hunter, ...
Blood 85 (12), 3412-3415, 1995
1551995
The urgent need for new antibacterial agents
R Wise, ...
Journal of antimicrobial chemotherapy 66 (9), 1939-1940, 2011
1512011
The CC-chemokine RANTES increases the attachment of human immunodeficiency virus type 1 to target cells via glycosaminoglycans and also activates a signal transduction pathway …
A Trkola, C Gordon, J Matthews, E Maxwell, T Ketas, L Czaplewski, ...
Journal of virology 73 (8), 6370-6379, 1999
1451999
Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay
NR Stokes, J Sievers, S Barker, JM Bennett, DR Brown, I Collins, ...
Journal of Biological Chemistry 280 (48), 39709-39715, 2005
1352005
Analysis of the clinical pipeline of treatments for drug-resistant bacterial infections: despite progress, more action is needed
MS Butler, V Gigante, H Sati, S Paulin, L Al-Sulaiman, JH Rex, ...
Antimicrobial agents and chemotherapy 66 (3), e01991-21, 2022
1332022
Aggregation of RANTES is responsible for its inflammatory properties: characterization of nonaggregating, noninflammatory RANTES mutants
V Appay, A Brown, S Cribbes, E Randle, LG Czaplewski
Journal of Biological Chemistry 274 (39), 27505-27512, 1999
1231999
Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical …
DJ Haydon, JM Bennett, D Brown, I Collins, G Galbraith, P Lancett, ...
Journal of medicinal chemistry 53 (10), 3927-3936, 2010
1212010
Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilis
LG Czaplewski, AK North, MCM Smith, S Baumberg, PG Stockley
Molecular microbiology 6 (2), 267-275, 1992
1121992
An Improved Small-Molecule Inhibitor of FtsZ with Superior In Vitro Potency, Drug-Like Properties, and In Vivo Efficacy
NR Stokes, N Baker, JM Bennett, J Berry, I Collins, LG Czaplewski, ...
Antimicrobial agents and chemotherapy 57 (1), 317-325, 2013
1102013
Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ
LG Czaplewski, I Collins, EA Boyd, D Brown, SP East, M Gardiner, ...
Bioorganic & medicinal chemistry letters 19 (2), 524-527, 2009
1092009
RANTES activates antigen-specific cytotoxic T lymphocytes in a mitogen-like manner through cell surface aggregation
V Appay, PR Dunbar, V Cerundolo, A McMichael, L Czaplewski, ...
International immunology 12 (8), 1173-1182, 2000
1042000
Multiple effects of benzamide antibiotics on FtsZ function
DW Adams, LJ Wu, LG Czaplewski, J Errington
Molecular microbiology 80 (1), 68-84, 2011
1012011
BB-10010: an active variant of human macrophage inflammatory protein-1 alpha with improved pharmaceutical properties
MG Hunter, L Bawden, D Brotherton, S Craig, S Cribbes, LG Czaplewski, ...
971995
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